Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1437
Título : Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
Autor : Abulafia, Carolina Andrea 
Loewenstein, David A. 
Curiel-Cid, Rosie 
Duarte-Abritta, Bárbara 
Sánchez, Stella M. 
Vigo, Daniel Eduardo 
Castro, Mariana N. 
Drucaroff, Lucas J. 
Vázquez, Silvia 
Sevlever, Gustavo 
Nemeroff, Charles B. 
Guinjoan, Salvador M. 
Villareal, Mirta F. 
Palabras clave : MEDICINAENFERMEDAD DE ALZHEIMERMEMORIA
Fecha de publicación : 2019
Editorial : American Psychiatric Association
Cita : Abulafia, C., et al. Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease [en línea]. Postprint del artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1). doi:10.1176/appi.neuropsych.17120355. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1437
Resumen : Abstract: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer’s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer’s disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer’s-relevant brain regions even at a relatively young age.
URI : https://repositorio.uca.edu.ar/handle/123456789/1437
ISSN : 1545-7222 (online)
Disciplina: MEDICINA
DOI: 10.1176/appi.neuropsych.17120355
Derechos: Acceso Abierto. 1 año de embargo
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