Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1437
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dc.contributor.authorAbulafia, Carolina Andreaes
dc.contributor.authorLoewenstein, David A.es
dc.contributor.authorCuriel-Cid, Rosiees
dc.contributor.authorDuarte-Abritta, Bárbaraes
dc.contributor.authorSánchez, Stella M.es
dc.contributor.authorVigo, Daniel Eduardoes
dc.contributor.authorCastro, Mariana N.es
dc.contributor.authorDrucaroff, Lucas J.es
dc.contributor.authorVázquez, Silviaes
dc.contributor.authorSevlever, Gustavoes
dc.contributor.authorNemeroff, Charles B.es
dc.contributor.authorGuinjoan, Salvador M.es
dc.contributor.authorVillareal, Mirta F.es
dc.date.accessioned2019-05-02T13:56:10Z-
dc.date.available2019-05-02T13:56:10Z-
dc.date.issued2019-
dc.identifier.citationAbulafia, C., et al. Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease [en línea]. Postprint del artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1). doi:10.1176/appi.neuropsych.17120355. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1437es
dc.identifier.issn1545-7222 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/1437-
dc.description.abstractAbstract: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer’s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer’s disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer’s-relevant brain regions even at a relatively young age.es
dc.formatapplication/pdfes
dc.languageenges
dc.language.isoenges
dc.publisherAmerican Psychiatric Associationes
dc.rightsAcceso Abierto. 1 año de embargoes
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/es
dc.sourcePostprint de artículo publicado en The Journal of Neuropsychiatry and Clinical Neurosciences. 2019, 31 (1)es
dc.subjectMEDICINAes
dc.subjectENFERMEDAD DE ALZHEIMERes
dc.subjectMEMORIAes
dc.titleBrain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's diseasees
dc.typeArtículoes
dc.identifier.doi10.1176/appi.neuropsych.17120355-
uca.pathFacultad de Ciencias Médicas|Instituto de Investigaciones Biomédicas (BIOMED UCA-CONICET)es
uca.disciplinaMEDICINAes
uca.filename/home/data-uca-generic/folder_generic/IIBiomedicas/brain-structural-amyloid-correlates/metadata.xmles
uca.issnrd1es
uca.affiliationFil: Abulafia, Carolina. Fundación Fleni; Argentinaes
uca.affiliationFil: Abulafia, Carolina. Pontificia Universidad Católica Argentina. Insituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Loewenstein, David A. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidoses
uca.affiliationFil: Curiel-Cid, Rosie. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidoses
uca.affiliationFil: Duarte-Abritta, Bárbara. Fundación Fleni; Argentinaes
uca.affiliationFil: Sánchez, Stella M. Fundación Fleni; Argentinaes
uca.affiliationFil: Sánchez, Stella M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Sánchez, Stella M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Na Departamento de Física; Argentinaes
uca.affiliationFil:Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Insituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Castro, Mariana N. Fundación Fleni; Argentinaes
uca.affiliationFil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentinaes
uca.affiliationFil: Drucaroff, Lucas J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Drucaroff, Lucas J. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentinaes
uca.affiliationFil: Vázquez, Silvia. Fundación Fleni; Argentinaes
uca.affiliationFil: Sevlever, Gustavo. Fundación Fleni; Argentinaes
uca.affiliationFil: Nemeroff, Charles B. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidoses
uca.affiliationFil: Guinjoan, Salvador M. Fundación Fleni; Argentinaes
uca.affiliationFil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Villareal, Mirta F. Fundación Fleni; Argentinaes
uca.affiliationFil: Villareal, Mirta F. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Villareal, Mirta F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentinaes
uca.versionacceptedVersiones
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptLaboratorio de Cronofisiología-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Cronofisiología-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0001-8239-7141-
crisitem.author.orcid0000-0003-2291-245X-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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