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Título : Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
Autor : Gao, Xinghua 
Cao, Qiuhua 
Cheng, Yan 
Zhao, Dandan 
Wang, Zhuo 
Yang, Hongbao 
Wu, Qijin 
You, Linjun 
Wang, Yue 
Lin, Yanting 
Li, Xianjing 
Wang, Yun 
Bian, Jin-Song 
Sun, Dongdong 
Kong, Lingyi 
Birnbaumer, Lutz 
Yang, Yong 
Palabras clave : ESTRESCOLITISMICROORGANISMOSSISTEMA INMUNOLOGICO
Fecha de publicación : 2018
Editorial : National Academy of Sciences
Cita : Gao X, Cao Q, Cheng Y, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969. doi:10.1073/pnas.1720696115 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8696
Resumen : Abstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in colonic lamina propria; and to present with decreased thymus and mesenteric lymph node (MLN) coefficients. Circulating total white blood cells were significantly increased after stress, and the proportion of MLN-associated immune cells were largely changed. Results showed a marked activation of IL-6/STAT3 signaling by stress. The detrimental action of stress was not terminated in IL-6-/- mice. Interestingly, the composition of gut microbiota was dramatically changed after stress, with expansion of inflammation-promoting bacteria. Furthermore, results showed stress-induced deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. Of note is that, in the case of cohousing, the stress-induced immune reaction and decreased body weight were abrogated, and transferred gut microbiota from stressed mice to control mice was sufficient to facilitate DSS-induced colitis. The important role of gut microbiota was further reinforced by broad-spectrum antibiotic treatment. Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis.
URI : https://repositorio.uca.edu.ar/handle/123456789/8696
ISSN : 1091-6490 (online)
Disciplina: MEDICINA
DOI: 10.1073/pnas.1720696115
Derechos: Acceso Abierto
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