Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/8696
Título : | Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response | Autor : | Gao, Xinghua Cao, Qiuhua Cheng, Yan Zhao, Dandan Wang, Zhuo Yang, Hongbao Wu, Qijin You, Linjun Wang, Yue Lin, Yanting Li, Xianjing Wang, Yun Bian, Jin-Song Sun, Dongdong Kong, Lingyi Birnbaumer, Lutz Yang, Yong |
Palabras clave : | ESTRES; COLITIS; MICROORGANISMOS; SISTEMA INMUNOLOGICO | Fecha de publicación : | 2018 | Editorial : | National Academy of Sciences | Cita : | Gao X, Cao Q, Cheng Y, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969. doi:10.1073/pnas.1720696115 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8696 | Resumen : | Abstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in colonic lamina propria; and to present with decreased thymus and mesenteric lymph node (MLN) coefficients. Circulating total white blood cells were significantly increased after stress, and the proportion of MLN-associated immune cells were largely changed. Results showed a marked activation of IL-6/STAT3 signaling by stress. The detrimental action of stress was not terminated in IL-6-/- mice. Interestingly, the composition of gut microbiota was dramatically changed after stress, with expansion of inflammation-promoting bacteria. Furthermore, results showed stress-induced deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. Of note is that, in the case of cohousing, the stress-induced immune reaction and decreased body weight were abrogated, and transferred gut microbiota from stressed mice to control mice was sufficient to facilitate DSS-induced colitis. The important role of gut microbiota was further reinforced by broad-spectrum antibiotic treatment. Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis. | URI : | https://repositorio.uca.edu.ar/handle/123456789/8696 | ISSN : | 1091-6490 (online) | Disciplina: | MEDICINA | DOI: | 10.1073/pnas.1720696115 | Derechos: | Acceso Abierto |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
chronic-stress-promotes-colitis.pdf | 2,71 MB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
194
comprobado en 18-oct-2024
Descarga(s)
244
comprobado en 18-oct-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons