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https://repositorio.uca.edu.ar/handle/123456789/8696
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Gao, Xinghua | es |
dc.contributor.author | Cao, Qiuhua | es |
dc.contributor.author | Cheng, Yan | es |
dc.contributor.author | Zhao, Dandan | es |
dc.contributor.author | Wang, Zhuo | es |
dc.contributor.author | Yang, Hongbao | es |
dc.contributor.author | Wu, Qijin | es |
dc.contributor.author | You, Linjun | es |
dc.contributor.author | Wang, Yue | es |
dc.contributor.author | Lin, Yanting | es |
dc.contributor.author | Li, Xianjing | es |
dc.contributor.author | Wang, Yun | es |
dc.contributor.author | Bian, Jin-Song | es |
dc.contributor.author | Sun, Dongdong | es |
dc.contributor.author | Kong, Lingyi | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Yang, Yong | es |
dc.date.accessioned | 2019-09-06T22:37:43Z | - |
dc.date.available | 2019-09-06T22:37:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Gao X, Cao Q, Cheng Y, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969. doi:10.1073/pnas.1720696115 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8696 | es |
dc.identifier.issn | 1091-6490 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8696 | - |
dc.description.abstract | Abstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in colonic lamina propria; and to present with decreased thymus and mesenteric lymph node (MLN) coefficients. Circulating total white blood cells were significantly increased after stress, and the proportion of MLN-associated immune cells were largely changed. Results showed a marked activation of IL-6/STAT3 signaling by stress. The detrimental action of stress was not terminated in IL-6-/- mice. Interestingly, the composition of gut microbiota was dramatically changed after stress, with expansion of inflammation-promoting bacteria. Furthermore, results showed stress-induced deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. Of note is that, in the case of cohousing, the stress-induced immune reaction and decreased body weight were abrogated, and transferred gut microbiota from stressed mice to control mice was sufficient to facilitate DSS-induced colitis. The important role of gut microbiota was further reinforced by broad-spectrum antibiotic treatment. Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis. | es |
dc.format | application/pdf | - |
dc.language.iso | eng | es |
dc.publisher | National Academy of Sciences | es |
dc.rights | Acceso Abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969 | es |
dc.subject | ESTRES | es |
dc.subject | COLITIS | es |
dc.subject | MICROORGANISMOS | es |
dc.subject | SISTEMA INMUNOLOGICO | es |
dc.title | Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1073/pnas.1720696115 | - |
dc.identifier.pmid | 29531080 | - |
uca.disciplina | MEDICINA | - |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Gao, Xinghua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Gao, Xinghua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Gao, Xinghua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China | es |
uca.affiliation | Fil: Cao, Qiuhua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Cao, Qiuhua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Cao, Qiuhua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China | es |
uca.affiliation | Fil: Cheng, Yan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Zhao, Dandan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Zhao, Dandan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Zhao, Dandan. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China | es |
uca.affiliation | Fil: Wang, Zhuo. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Wang, Zhuo. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Wang, Zhuo. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China | es |
uca.affiliation | Fil: Wang, Zhuo. Nanjing University of Chinese Medicine. Translational Medicine Center; China | es |
uca.affiliation | Fil: Yang, Hongbao. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Yang, Hongbao. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Yang, Hongbao. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China | es |
uca.affiliation | Fil: Wu, Qijin. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Wu, Qijin. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Wu, Qijin. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China | es |
uca.affiliation | Fil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: You, Linjun. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Lin, Yanting. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Li, Xianjing. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Bian, Jin-Song. National University of Singapore. Yong Loo Lin School of Medicine. Department of Pharmacology; Singapur | es |
uca.affiliation | Fil: Sun, Dongdong. Nanjing University of Chinese Medicine. Translational Medicine Center; China | es |
uca.affiliation | Fil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Kong, Lingyi. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.affiliation | Fil: Yang, Yong. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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