Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8696
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dc.contributor.authorGao, Xinghuaes
dc.contributor.authorCao, Qiuhuaes
dc.contributor.authorCheng, Yanes
dc.contributor.authorZhao, Dandanes
dc.contributor.authorWang, Zhuoes
dc.contributor.authorYang, Hongbaoes
dc.contributor.authorWu, Qijines
dc.contributor.authorYou, Linjunes
dc.contributor.authorWang, Yuees
dc.contributor.authorLin, Yantinges
dc.contributor.authorLi, Xianjinges
dc.contributor.authorWang, Yunes
dc.contributor.authorBian, Jin-Songes
dc.contributor.authorSun, Dongdonges
dc.contributor.authorKong, Lingyies
dc.contributor.authorBirnbaumer, Lutzes
dc.contributor.authorYang, Yonges
dc.date.accessioned2019-09-06T22:37:43Z-
dc.date.available2019-09-06T22:37:43Z-
dc.date.issued2018-
dc.identifier.citationGao X, Cao Q, Cheng Y, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969. doi:10.1073/pnas.1720696115 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8696es
dc.identifier.issn1091-6490 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/8696-
dc.description.abstractAbstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in colonic lamina propria; and to present with decreased thymus and mesenteric lymph node (MLN) coefficients. Circulating total white blood cells were significantly increased after stress, and the proportion of MLN-associated immune cells were largely changed. Results showed a marked activation of IL-6/STAT3 signaling by stress. The detrimental action of stress was not terminated in IL-6-/- mice. Interestingly, the composition of gut microbiota was dramatically changed after stress, with expansion of inflammation-promoting bacteria. Furthermore, results showed stress-induced deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. Of note is that, in the case of cohousing, the stress-induced immune reaction and decreased body weight were abrogated, and transferred gut microbiota from stressed mice to control mice was sufficient to facilitate DSS-induced colitis. The important role of gut microbiota was further reinforced by broad-spectrum antibiotic treatment. Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis.es
dc.formatapplication/pdf-
dc.language.isoenges
dc.publisherNational Academy of Scienceses
dc.rightsAcceso Abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceProceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969es
dc.subjectESTRESes
dc.subjectCOLITISes
dc.subjectMICROORGANISMOSes
dc.subjectSISTEMA INMUNOLOGICOes
dc.titleChronic stress promotes colitis by disturbing the gut microbiota and triggering immune system responsees
dc.typeArtículoes
dc.identifier.doi10.1073/pnas.1720696115-
dc.identifier.pmid29531080-
uca.disciplinaMEDICINA-
uca.issnrd1es
uca.affiliationFil: Gao, Xinghua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Gao, Xinghua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Gao, Xinghua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; Chinaes
uca.affiliationFil: Cao, Qiuhua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Cao, Qiuhua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Cao, Qiuhua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; Chinaes
uca.affiliationFil: Cheng, Yan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Zhao, Dandan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Zhao, Dandan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Zhao, Dandan. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; Chinaes
uca.affiliationFil: Wang, Zhuo. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Wang, Zhuo. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Wang, Zhuo. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; Chinaes
uca.affiliationFil: Wang, Zhuo. Nanjing University of Chinese Medicine. Translational Medicine Center; Chinaes
uca.affiliationFil: Yang, Hongbao. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Yang, Hongbao. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Yang, Hongbao. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; Chinaes
uca.affiliationFil: Wu, Qijin. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Wu, Qijin. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Wu, Qijin. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; Chinaes
uca.affiliationFil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: You, Linjun. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Lin, Yanting. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Li, Xianjing. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Bian, Jin-Song. National University of Singapore. Yong Loo Lin School of Medicine. Department of Pharmacology; Singapures
uca.affiliationFil: Sun, Dongdong. Nanjing University of Chinese Medicine. Translational Medicine Center; Chinaes
uca.affiliationFil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Kong, Lingyi. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidoses
uca.affiliationFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.affiliationFil: Yang, Yong. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; Chinaes
uca.affiliationFil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; Chinaes
uca.versionpublishedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Función y Farmacología de Canales Iónicos-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.orcid0000-0002-0775-8661-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
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