Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8670
Título : A visible-light-sensitive caged serotonin
Autor : Cabrera, Ricardo 
Filevich, Oscar 
García-Acosta, Beatriz 
Athilingam, Jegath 
Bender, Kevin J. 
Poskanzer, Kira E. 
Etchenique, Roberto 
Palabras clave : NEUROFISIOLOGIASEROTONINAFOTOQUIMICA
Fecha de publicación : 2017
Editorial : American Chemical Society
Cita : Cabrera R, Filevich O, García-Acosta B, et al. A Visible-Light-Sensitive Caged Serotonin. ACS Chemical Neuroscience 2017;8(5):1036-1042. doi:10.1021/acschemneuro.7b00083 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8670
Resumen : Abstract: Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons.
URI : https://repositorio.uca.edu.ar/handle/123456789/8670
ISSN : 1948-7193 (print)
1948-7193 (online)
Disciplina: MEDICINA
DOI: 10.1021/acschemneuro.7b00083
Derechos: Acceso Abierto. 12 meses de embargo
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat
visible-light-sensitive-caged.pdf560,63 kBAdobe PDFThumbnail
View/Open
visible-light-sensitive-caged.jpg5,37 kBJPEGThumbnail
View/Open
Show full item record

Page view(s)

122
checked on Mar 8, 2021

Download(s)

96
checked on Mar 8, 2021

Google ScholarTM

Check


Altmetric


This item is licensed under a Creative Commons License Creative Commons