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Título : A visible-light-sensitive caged serotonin
Autor : Cabrera, Ricardo 
Filevich, Oscar 
García-Acosta, Beatriz 
Athilingam, Jegath 
Bender, Kevin J. 
Poskanzer, Kira E. 
Etchenique, Roberto 
Fecha de publicación : 2017
Editorial : American Chemical Society
Cita : Cabrera R, Filevich O, García-Acosta B, et al. A Visible-Light-Sensitive Caged Serotonin. ACS Chemical Neuroscience 2017;8(5):1036-1042. doi:10.1021/acschemneuro.7b00083 Disponible en:
Resumen : Abstract: Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons.
ISSN : 1948-7193 (print)
1948-7193 (online)
Disciplina: MEDICINA
DOI: 10.1021/acschemneuro.7b00083
Derechos: Acceso Abierto. 12 meses de embargo
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