Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/15119
Título : Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics
Autor : Naranjo, María Eugenia G. 
Rodrigues Soares, Fernanda 
Peñas Lledó, Eva M. 
Tarazona Santos, Eduardo 
Fariñas, Humberto 
Rodeiro, Idania 
Terán, Enrique 
Grazina, Manuela 
Moya, Graciela E. 
López López, Marisol 
Sarmiento, Alba P. 
Calzadilla, Luis R. 
Ramírez Roa, Ronald 
Ortiz López, Rocío 
Estévez Carrizo, Francisco E. 
Sosa Macías, Martha 
Barrantes, Ramiro 
LLerena, Adrián 
Palabras clave : FARMACOGENETICAGENOTIPOSCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9Cytochrome P-450 CYP2D6
Fecha de publicación : 2018
Editorial : Mary Ann Liebert
Cita : Naranjo, M.E.G., et al. Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics [en línea]. OMICS: A Journal of Integrative Biology. 2018, 22(09) doi:10.1089/omi.2018.0114 Disponible en:
Resumen : Abstarct Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations in CYP2D6, CYP2C9, and CYP2C19 drug metabolizing enzyme genotypes, which were subsequently utilized to catalog their "predicted drug metabolism phenotypes" across Native American and Ibero American populations. Importantly, we report in this study, a total of 6060 healthy individuals from Ibero-America who were classified according to their self-reported ancestry: 1395 Native Americans, 2571 Admixed Latin Americans, 96 Afro-Latin Americans, 287 white Latin Americans (from Cuba), 1537 Iberians, and 174 Argentinean Ashkenazi Jews. Moreover, Native Americans were grouped into North-, Central-, and South Amerindians (from Mexico, Costa Rica, and Peru, respectively). All subjects were studied for the most common and functional CYP2D6, CYP2C9, and CYP2C19 allelic variants, and grouped as genotype-predicted poor or ultrarapid metabolizer phenotypes (gPMs and gUMs, respectively). Native Americans showed differences from each ethnic group in at least two alleles of CYP2D6, CYP2C9, and CYP2C19. Native Americans had higher frequencies of wild-type alleles for all genes, and lower frequency of CYP2D6*41, CYP2C9*2, and CYP2C19*17 (p < 0.05). Native Americans also showed less CYP2C19 gUMs than the rest of the population sample. In addition, differences within Native Americans (mostly North vs. South) were also found. The interethnic differences described supports the need for population-specific personalized and precision medicine programs for Native Americans. To the best of our knowledge, this is the largest study carried out in Native Americans and other Ibero-American populations analyzing CYP2D6, CYP2C9, and CYP2C19 genetic polymorphisms. Population pharmacogenomics is a nascent field of global health and warrants further research and education.
URI : https://repositorio.uca.edu.ar/handle/123456789/15119
Disciplina: MEDICINA
DOI: 10.1089/omi.2018.0114
Derechos: info:eu-repo/semantics/closedAccess
Aparece en las colecciones: Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato Usuarios registrados haga click en: Login
Interethnic-variability.pdf373,76 kBAdobe PDF  
thumb.jpg444,37 kBJPEGVista previa
Visualizar/Abrir
Mostrar el registro Dublin Core completo del ítem

Visualizaciones de página(s)

58
comprobado en 28-mar-2024

Descarga(s)

15
comprobado en 28-mar-2024

Google ScholarTM

Consultar


Altmetric


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons