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Título : Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
Autor : Abulafia, Carolina Andrea 
Duarte-Abritta, Bárbara 
Villareal, Mirta F. 
Ladrón-de-Guevara, María S. 
García, Celeste 
Sequeyra, Geraldine 
Sevlever, Gustavo 
Fiorentini, Leticia 
Bär, Karl-Jürgen 
Gustafson, Deborah R. 
Vigo, Daniel Eduardo 
Guinjoan, Salvador M. 
Fecha de publicación : 2017
Editorial : Frontiers Media
Cita : Abulafia, C., et al. Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease [en línea]. Frontiers in Aging Neuroscience. 2017, 9. doi:10.3389/fnagi.2017.00093. Disponible en:
Resumen : Abstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer’s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep–wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t D 4.97, df D 49, p < 0.01) and language (Weschler’s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t D 2.49, df D 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t D 2.48, df D 40, p D 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep–wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
ISSN : 1663-4365 (online)
Disciplina: MEDICINA
DOI: 10.3389/fnagi.2017.00093
Derechos: Acceso Abierto
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