Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1463
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dc.contributor.authorAbulafia, Carolina Andreaes
dc.contributor.authorDuarte-Abritta, Bárbaraes
dc.contributor.authorVillareal, Mirta F.es
dc.contributor.authorLadrón-de-Guevara, María S.es
dc.contributor.authorGarcía, Celestees
dc.contributor.authorSequeyra, Geraldinees
dc.contributor.authorSevlever, Gustavoes
dc.contributor.authorFiorentini, Leticiaes
dc.contributor.authorBär, Karl-Jürgenes
dc.contributor.authorGustafson, Deborah R.es
dc.contributor.authorVigo, Daniel Eduardoes
dc.contributor.authorGuinjoan, Salvador M.es
dc.date.accessioned2019-05-02T13:56:20Z-
dc.date.available2019-05-02T13:56:20Z-
dc.date.issued2017-
dc.identifier.citationAbulafia, C, Duarte-Abritta, B, Villareal, MF, et al. Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease [en línea]. Frontiers in Aging Neuroscience , Vol. 9, 2017. Disponible en: https://www.frontiersin.org/articles/10.3389/fnagi.2017.00093/full [Fecha de consulta: ….] doi: 10.3389/fnagi.2017.00093 Registro disponible en: http://bibliotecadigital.uca.edu.ar/greenstone/cgi-bin/library.cgi?a=d&c=investigacion&d=relationship-cognitive-sleep-wakees
dc.identifier.issn1663-4365 (electrónico)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/1463-
dc.description.abstractAbstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer’s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep–wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t D 4.97, df D 49, p < 0.01) and language (Weschler’s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t D 2.49, df D 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t D 2.48, df D 40, p D 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep–wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.es
dc.description.abstractFil. García, Celeste. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
dc.formatapplication/pdfes
dc.languagespaes
dc.publisherFrontiers Mediaes
dc.rightsAcceso Abiertoes
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/es
dc.sourceFrontiers in Aging Neuroscience, Vol. 9, 2017es
dc.sourceISSN 1663-4365 (electrónico)es
dc.subjectENFERMEDAD DE ALZHEIMERes
dc.subjectPROCESO COGNITIVOes
dc.subjectSUEÑOes
dc.subjectRITMO CIRCADIANOes
dc.titleRelationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s diseasees
dc.typeArtículoes
dc.identifier.doi10.3389/fnagi.2017.00093-
uca.pathFacultad de Ciencias Médicas|Instituto de Investigaciones Biomédicas (BIOMED UCA-CONICET)es
uca.disciplinaBIOLOGIAes
uca.filename/home/data-uca-generic/folder_generic/IIBiomedicas/relationship-cognitive-sleep-wake/metadata.xmles
uca.issnrd1es
uca.affiliationFil: Abulafia, Carolina. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
uca.affiliationFil: Abulafia, Carolina. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada; Argentinaes
uca.affiliationFil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Duarte-Abritta, Bárbara. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
uca.affiliationFil: Villareal, Mirta F. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
uca.affiliationFil: Villareal, Mirta F. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Ladrón-de-Guevara, María S. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
uca.affiliationFil: Ladrón-de-Guevara, María S. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Sequeyra, Geraldine. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
uca.affiliationFil: Sevlever, Gustavo. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
uca.affiliationFil: Fiorentini, Leticia. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
uca.affiliationFil: Bär, Karl-Jürgen. Friedrich-Schiller-Universität. Universitätsklinikum Jena. Department of Psychiatry and Psychotherapy; Alemaniaes
uca.affiliationFil: Gustafson, Deborah R. State University of New York. Downstate Medical Center. Department of Neurology; Estados Unidoses
uca.affiliationFil: Gustafson, Deborah R. University of Gothenburg. Neuropsychiatric Epidemiology Unit; Sueciaes
uca.affiliationFil: Gustafson, Deborah R. University of Skövde. Department of Health and Education; Sueciaes
uca.affiliationFil: Vigo Daniel E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada; Argentinaes
uca.affiliationFil: Vigo Daniel E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Guinjoan, Salvador M. Fundacion De Altos Estudios Univeristarios Fleni. Departamento de Psiquiatría; Argentinaes
uca.affiliationFil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Fundacion De Altos Estudios Univeristarios Fleni. Unidad Educativa. Departamento de Psiquiatría y Salud Mental; Argentinaes
uca.affiliationFil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Psicología. Departamento de Neurofisiología; Argentinaes
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptLaboratorio de Cronofisiología-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Cronofisiología-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0001-8239-7141-
crisitem.author.orcid0000-0003-2291-245X-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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