Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/9360
Título : | Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway | Autor : | Cheng, Yan Xing-Hua, Gao Li, Xian-Jing Cao, Qiuhua Zhao, Dan-Dan Zhou, Jin-Rong Wu, Hong-Xi Wang, Yun You, Lin-Jun Yang, Hong-Bao He, Yun Long Li, Yong-Ren Bian, Jin-Song Zhu, Qing-Yi Birnbaumer, Lutz Yang, Yong |
Palabras clave : | CANCER; DEPRESION; METASTASIS; TRATAMIENTO MEDICO | Fecha de publicación : | 2018 | Editorial : | Springer Nature | Cita : | Cheng, Y., Xing-Hua, G., Li, Xian-J., et al. Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway [en línea]. Oncogene. 2018, 37. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9360 | Resumen : | Abstract: Depression drives cancer progression and induces poor clinical outcome. However, the mechanisms underlying depression and cancer outcomes are unclear. In this work, we investigated 98 prostate cancer patients and found that patients with high score of psychological depression were correlated with tumor invasion and metastasis. We found focal adhesion kinase (FAK) was increased in cancer patients with metastatic features and high score of depression. FAK knockdown completely blocked depression-promoted tumor invasion in orthotopic transplantation tumors. In Hi-myc mice and a murine model of depression, sympathetic activation was detected in the prostate tissue. Further we showed that FAK activation was dependent on a cAMP-PKA signaling pathway. Our results demonstrated that the activation of a sympathetic-FAK signaling pathway in prostate cancer patients with high degrees of depression facilitates tumor invasion. We suggest that blocking β2AR with propranolol or inhibiting FAK activation with PF562 271 may be novel strategies for depressed patients with invasive prostate cancer. | URI : | https://repositorio.uca.edu.ar/handle/123456789/9360 | ISSN : | 0950-9232 (impreso) 1476-5594 (en línea) |
Disciplina: | MEDICINA | DOI: | 10.1038/s41388-018-0177-4 | Derechos: | Acceso Abierto |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
depression-promotes-prostate-cancer.pdf | 779,77 kB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
212
comprobado en 27-abr-2024
Descarga(s)
844
comprobado en 27-abr-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons