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Título : Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
Autor : Cheng, Yan 
Xing-Hua, Gao 
Li, Xian-Jing 
Cao, Qiu-Hua 
Zhao, Dan-Dan 
Zhou, Jin-Rong 
Wu, Hong-Xi 
Wang, Yun 
You, Lin-Jun 
Yang, Hong-Bao 
He, Yun-Long 
Li, Yong-Ren 
Bian, Jin-Song 
Zhu, Qing-Yi 
Birnbaumer, Lutz 
Yang, Yong 
Fecha de publicación : 2018
Editorial : Springer Nature
Cita : Cheng, Y., Xing-Hua, G., Li, Xian-J., et al. Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway [en línea]. Oncogene. 2018, 37. Disponible en:
Resumen : Abstract: Depression drives cancer progression and induces poor clinical outcome. However, the mechanisms underlying depression and cancer outcomes are unclear. In this work, we investigated 98 prostate cancer patients and found that patients with high score of psychological depression were correlated with tumor invasion and metastasis. We found focal adhesion kinase (FAK) was increased in cancer patients with metastatic features and high score of depression. FAK knockdown completely blocked depression-promoted tumor invasion in orthotopic transplantation tumors. In Hi-myc mice and a murine model of depression, sympathetic activation was detected in the prostate tissue. Further we showed that FAK activation was dependent on a cAMP-PKA signaling pathway. Our results demonstrated that the activation of a sympathetic-FAK signaling pathway in prostate cancer patients with high degrees of depression facilitates tumor invasion. We suggest that blocking β2AR with propranolol or inhibiting FAK activation with PF562 271 may be novel strategies for depressed patients with invasive prostate cancer.
ISSN : 0950-9232 (impreso)
1476-5594 (en línea)
Disciplina: MEDICINA
DOI: 10.1038/s41388-018-0177-4
Derechos: Acceso Abierto
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