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https://repositorio.uca.edu.ar/handle/123456789/9360
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Cheng, Yan | es |
dc.contributor.author | Xing-Hua, Gao | es |
dc.contributor.author | Li, Xian-Jing | es |
dc.contributor.author | Cao, Qiuhua | es |
dc.contributor.author | Zhao, Dan-Dan | es |
dc.contributor.author | Zhou, Jin-Rong | es |
dc.contributor.author | Wu, Hong-Xi | es |
dc.contributor.author | Wang, Yun | es |
dc.contributor.author | You, Lin-Jun | es |
dc.contributor.author | Yang, Hong-Bao | es |
dc.contributor.author | He, Yun Long | es |
dc.contributor.author | Li, Yong-Ren | es |
dc.contributor.author | Bian, Jin-Song | es |
dc.contributor.author | Zhu, Qing-Yi | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Yang, Yong | es |
dc.date.accessioned | 2020-02-11T22:43:34Z | - |
dc.date.available | 2020-02-11T22:43:34Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Cheng, Y., Xing-Hua, G., Li, Xian-J., et al. Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway [en línea]. Oncogene. 2018, 37. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9360 | es |
dc.identifier.issn | 0950-9232 (impreso) | - |
dc.identifier.issn | 1476-5594 (en línea) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/9360 | - |
dc.description.abstract | Abstract: Depression drives cancer progression and induces poor clinical outcome. However, the mechanisms underlying depression and cancer outcomes are unclear. In this work, we investigated 98 prostate cancer patients and found that patients with high score of psychological depression were correlated with tumor invasion and metastasis. We found focal adhesion kinase (FAK) was increased in cancer patients with metastatic features and high score of depression. FAK knockdown completely blocked depression-promoted tumor invasion in orthotopic transplantation tumors. In Hi-myc mice and a murine model of depression, sympathetic activation was detected in the prostate tissue. Further we showed that FAK activation was dependent on a cAMP-PKA signaling pathway. Our results demonstrated that the activation of a sympathetic-FAK signaling pathway in prostate cancer patients with high degrees of depression facilitates tumor invasion. We suggest that blocking β2AR with propranolol or inhibiting FAK activation with PF562 271 may be novel strategies for depressed patients with invasive prostate cancer. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.rights | Acceso Abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Oncogene. 2018, 37 | es |
dc.subject | CANCER | es |
dc.subject | DEPRESION | es |
dc.subject | METASTASIS | es |
dc.subject | TRATAMIENTO MEDICO | es |
dc.title | Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1038/s41388-018-0177-4 | - |
dc.identifier.pmid | 29515233 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Cheng, Yan. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Xing-Hua, Gao. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Li, Xian-Jing. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Cao, Qiu-Hua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Zhao, Dan-Dan. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Zhou, Jin-Rong. Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Surgery. Nutrition/Metabolism Laboratory; Estados Unidos | es |
uca.affiliation | Fil: Wu, Hong-Xi. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Wang, Yun. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: You, Lin-Jun. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Yang, Hong-Bao. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: He, Yun-Long. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Li, Yong-Ren. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.affiliation | Fil: Bian, Jin-Song. National University of Singapore. Yong Loo Lin School of Medicine. Department of Pharmacology; Singapur | es |
uca.affiliation | Fil: Zhu, Qing-Yi. Jiangsu Province Hospital of Traditional Chinese Medicine. Department of Urology; China | es |
uca.affiliation | Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Yang, Yong. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research. State Key Laboratory of Natural Medicines. Key Laboratory of Drug Discovery for Metabolic Disease; China | es |
uca.version | acceptedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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