Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8795
Título : Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
Autor : Perona, Marina 
Thomasz, Lisa 
Rossich, Luciano 
Rodríguez, Carla 
Pisarev, Mario A. 
Rosemblit, Cinthia 
Cremaschi, Graciela A. 
Dagrosa, María Alejandra 
Juvenal, Guillermo J. 
Palabras clave : CANCERGLANDULA TIROIDESENZIMASADNRADIOSENSIBILIDAD
Fecha de publicación : 2018
Editorial : Elsevier
Cita : Perona M, Thomasz L, Rossich L, et al. Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid [en línea]. Postprint del artículo publicado en Molecular and Cellular Endocrinology. 2018;478:141-150. doi:https://doi.org/10.1016/j.mce.2018.08.007 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8795
Resumen : Abstract: Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to conventional therapy. Our purpose was to study the combined effect of HDAC inhibitors (HDACi) and ionizing irradiation in thyroid cancer cell lines (Nthy-ori 3-1, WRO, TPC-1 and 8505c). HDACi radiosensitized thyroid cancer cells as evidenced by the reduction of survival fraction, whereas they had no effect in the normal cells. HDACi enhanced radiation-induced cell death in WRO cells. Gamma-H2AX foci number increased and persisted long after ionizing exposure in the HDACi-treated cells (WRO and TPC-1). Moreover, the expression of the repair-related gene Ku80 was differentially modulated only in the cancer cells, by the compounds at the protein and/or mRNA levels. We present in vitro evidence that HDACi can enhance the radiosensitivity of human thyroid cancer cells.
URI : https://repositorio.uca.edu.ar/handle/123456789/8795
ISSN : 0303-7207 (impreso)
1872-8057 (online)
Disciplina: MEDICINA
DOI: 10.1016/j.mce.2018.08.007
Derechos: Acceso abierto. 12 meses de embargo
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat Existent users please Login
radiosensitivity-enhancement-human-thyroid.pdf1,88 MBAdobe PDF???org.dspace.app.webui.jsptag.ItemTag.embargo???    Request a copy
radiosensitivity-enhancement-human-thyroid.jpg1,77 MBJPEGThumbnail
View/Open
Show full item record

Page view(s)

192
checked on Sep 19, 2020

Download(s)

143
checked on Sep 19, 2020

Google ScholarTM

Check


Altmetric


This item is licensed under a Creative Commons License Creative Commons