Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8782
Título : Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug?
Autor : Di Rosso, María Emilia 
Palumbo, María Laura 
Genaro, Ana María 
Palabras clave : ANTIDEPRESIVOSDEPRESIONSISTEMA INMUNOLOGICOSEROTONINA
Fecha de publicación : 2016
Editorial : Elsevier
Cita : Di Rosso ME, Palumbo ML, Genaro AM. Immunomodulatory effects of fluoxetine : a new potential pharmacological action for a classic antidepressant drug? [en línea]. Pharmacological Research. 2016;109:101-107. doi:10.1016/j.phrs.2015.11.021 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8782
Resumen : Abstract: Selective serotonin reuptake inhibitors are frequently used antidepressants. In particular, fluoxetine is usually chosen for the treatment of the symptoms of depression, obsessive-compulsive, panic attack and bulimia nervosa. Antidepressant therapy has been associated with immune dysfunction. However, there is contradictory evidence about the effect of fluoxetine on the immune system. Experimental findings indicate that lymphocytes express the serotonin transporter. Moreover it has been shown that fluoxetine is able to modulate the immune function through a serotonin-dependent pathway and through a novel independent mechanism. In addition, several studies have shown that fluoxetine can alter tumor cell viability. Thus, it was recently demonstrated in vivo that chronic fluoxetine treatment inhibits tumor growth by increasing antitumor T-cell activity. Here we briefly review some of the literature referring to how fluoxetine is able to modify, for better or worse, the functionality of the immune system. These results of our analysis point to the relevance of the novel pharmacological action of this drug as an immunomodulator helping to treat several pathologies in which immune deficiency and/or deregulation is present.
URI : https://repositorio.uca.edu.ar/handle/123456789/8782
ISSN : 1043-6618 (impreso)
1096-1186 (online)
Disciplina: MEDICINA
DOI: 10.1016/j.phrs.2015.11.021
Derechos: Acceso abierto. 12 meses de embargo
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat Existent users please Login
immunomodulatory-effects-fluoxetine-new.pdf590,94 kBAdobe PDF???org.dspace.app.webui.jsptag.ItemTag.embargo???    Request a copy
immunomodulatory-effects-fluoxetine-new.jpg3,73 kBJPEGThumbnail
View/Open
Show full item record

Page view(s)

34
checked on Jan 21, 2020

Download(s)

13
checked on Jan 21, 2020

Google ScholarTM

Check


Altmetric


This item is licensed under a Creative Commons License Creative Commons