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Título : | TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice | Autor : | Phelan, Kevin D. Shwe, U Thaung Cozart, Michael A. Wu, Hong Mock, Matthew M. Abramowitz, Joel Birnbaumer, Lutz Zheng, Fang |
Palabras clave : | ELECTROENCEFALOGRAFIA; NEURONAS; ANALISIS ESPECTRAL; SISTEMA NERVIOSO; MEDICAMENTOS; EPILEPSIA | Fecha de publicación : | 2017 | Editorial : | Wiley | Cita : | Phelan KD, Shwe UT, Cozart MA, et al. TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice [en línea]. Epilepsia. 2017;58(2):247-254. doi:10.1111/epi.13648 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8738 | Resumen : | Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE). | URI : | https://repositorio.uca.edu.ar/handle/123456789/8738 | ISSN : | 0013-9580 1528-1167 (online) |
Disciplina: | MEDICINA | DOI: | 10.1111/epi.13648 | Derechos: | Acceso Abierto |
Appears in Collections: | Artículos |
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