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Título : Gαi proteins are indispensable for hearing
Autor : Beer-Hammer, Sandra 
Lee, Sze Chim 
Mauriac, Stephanie A. 
Leiss, Veronika 
Groh, Isabel A. M. 
Novakovic, Ana 
Piekorz, Roland P. 
Bucher, Kirsten 
Chen, Chengfang 
Ni, Kun 
Singer, Wibke 
Harasztosi, Csaba 
Schimmang, Thomas 
Zimmermann, Ulrike 
Pfeffer, Klaus 
Birnbaumer, Lutz 
Forge, Andrew 
Montcouquiol, Mireille 
Knipper, Marlies 
Nürnberg, Bernd 
Rüttiger, Lukas 
Fecha de publicación : 2018
Cita : Beer-Hammer S, Lee SC, Mauriac SA, et al. Gαi Proteins are Indispensable for Hearing [en línea]. Cellular Physiology and Biochemistry. 2018;47(4):1509-1532. doi:10.1159/000490867 Disponible en:
Resumen : Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear.
ISSN : 1015-8987
1421-9778 (online)
Disciplina: MEDICINA
DOI: 10.1159/000490867
Derechos: Acceso Abierto
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