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dc.contributor.authorBeer-Hammer, Sandraes
dc.contributor.authorLee, Sze Chimes
dc.contributor.authorMauriac, Stephanie A.es
dc.contributor.authorLeiss, Veronikaes
dc.contributor.authorGroh, Isabel A. M.es
dc.contributor.authorNovakovic, Anaes
dc.contributor.authorPiekorz, Roland P.es
dc.contributor.authorBucher, Kirstenes
dc.contributor.authorChen, Chengfanges
dc.contributor.authorNi, Kunes
dc.contributor.authorSinger, Wibkees
dc.contributor.authorHarasztosi, Csabaes
dc.contributor.authorSchimmang, Thomases
dc.contributor.authorZimmermann, Ulrikees
dc.contributor.authorPfeffer, Klauses
dc.contributor.authorBirnbaumer, Lutzes
dc.contributor.authorForge, Andrewes
dc.contributor.authorMontcouquiol, Mireillees
dc.contributor.authorKnipper, Marlieses
dc.contributor.authorNürnberg, Berndes
dc.contributor.authorRüttiger, Lukases
dc.date.accessioned2019-09-06T16:46:08Z-
dc.date.available2019-09-06T16:46:08Z-
dc.date.issued2018-
dc.identifier.citationBeer-Hammer S, Lee SC, Mauriac SA, et al. Gαi Proteins are Indispensable for Hearing [en línea]. Cellular Physiology and Biochemistry. 2018;47(4):1509-1532. doi:10.1159/000490867 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8692es
dc.identifier.issn1015-8987-
dc.identifier.issn1421-9778 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/8692-
dc.description.abstractAbstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear.es
dc.formatapplication/pdf-
dc.language.isoenges
dc.rightsAcceso Abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceCellular Physiology and Biochemistry. 2018;47(4):1509-1532es
dc.subjectGENESes
dc.subjectAUDICIONes
dc.subjectPROTEINASes
dc.subjectSORDERAes
dc.subjectPERDIDA AUDITIVAes
dc.subjectMODIFICIACION GENETICAes
dc.titleGαi proteins are indispensable for hearinges
dc.typeArtículoes
dc.identifier.doi10.1159/000490867-
dc.identifier.pmid29940568-
uca.disciplinaMEDICINA-
uca.issnrd1es
uca.affiliationFil: Beer-Hammer, Sandra. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemaniaes
uca.affiliationFil: Lee, Sze Chim. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemaniaes
uca.affiliationFil: Mauriac, Stephanie A. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Franciaes
uca.affiliationFil: Mauriac, Stephanie A. University of Bordeaux. Neurocentre Magendie; Franciaes
uca.affiliationFil: Leiss, Veronika. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemaniaes
uca.affiliationFil: Groh, Isabel A. M. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemaniaes
uca.affiliationFil: Novakovic, Ana. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemaniaes
uca.affiliationFil: Piekorz, Roland P. University of Düsseldorf. Medical Faculty. Institute for Biochemistry and Molecular Biology II; Alemaniaes
uca.affiliationFil: Bucher, Kirsten. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemaniaes
uca.affiliationFil: Chen, Chengfang. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemaniaes
uca.affiliationFil: Ni, Kun. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemaniaes
uca.affiliationFil: Singer, Wibke. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemaniaes
uca.affiliationFil: Harasztosi, Csaba. University of Tübingen. Section of Physiological Acoustics and Communication. Tübingen Hearing Research Center. Department of Otolaryngology; Alemaniaes
uca.affiliationFil: Schimmang, Thomas. Universidad de Valladolid. Instituto de Biologíay Genética Molecular; Españaes
uca.affiliationFil: Schimmang, Thomas. Consejo Superior de Investigaciones Científicas; Españaes
uca.affiliationFil: Zimmermann, Ulrike. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. bMolecular Physiology of Hearing; Alemaniaes
uca.affiliationFil: Pfeffer, Klaus. University of Düsseldorf. Institute of Medical Microbiology and Hospital Hygiene; Alemaniaes
uca.affiliationFil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences, National Institute of Health. Neurobiology Laboratory; Estados Unidoses
uca.affiliationFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Forge, Andrew. University College London. Ear Institute; Reino Unidoes
uca.affiliationFil: Montcouquiol, Mireille. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Franciaes
uca.affiliationFil: Montcouquiol, Mireille. University of Bordeaux. Neurocentre Magendie; Franciaes
uca.affiliationFil: Knipper, Marlies. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemaniaes
uca.affiliationFil: Nürnberg, Bernd. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemaniaes
uca.affiliationFil: Rüttiger, Lukas. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Franciaes
uca.versionpublishedVersiones
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Función y Farmacología de Canales Iónicos-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0002-0775-8661-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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