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https://repositorio.uca.edu.ar/handle/123456789/8692
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Beer-Hammer, Sandra | es |
dc.contributor.author | Lee, Sze Chim | es |
dc.contributor.author | Mauriac, Stephanie A. | es |
dc.contributor.author | Leiss, Veronika | es |
dc.contributor.author | Groh, Isabel A. M. | es |
dc.contributor.author | Novakovic, Ana | es |
dc.contributor.author | Piekorz, Roland P. | es |
dc.contributor.author | Bucher, Kirsten | es |
dc.contributor.author | Chen, Chengfang | es |
dc.contributor.author | Ni, Kun | es |
dc.contributor.author | Singer, Wibke | es |
dc.contributor.author | Harasztosi, Csaba | es |
dc.contributor.author | Schimmang, Thomas | es |
dc.contributor.author | Zimmermann, Ulrike | es |
dc.contributor.author | Pfeffer, Klaus | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Forge, Andrew | es |
dc.contributor.author | Montcouquiol, Mireille | es |
dc.contributor.author | Knipper, Marlies | es |
dc.contributor.author | Nürnberg, Bernd | es |
dc.contributor.author | Rüttiger, Lukas | es |
dc.date.accessioned | 2019-09-06T16:46:08Z | - |
dc.date.available | 2019-09-06T16:46:08Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Beer-Hammer S, Lee SC, Mauriac SA, et al. Gαi Proteins are Indispensable for Hearing [en línea]. Cellular Physiology and Biochemistry. 2018;47(4):1509-1532. doi:10.1159/000490867 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8692 | es |
dc.identifier.issn | 1015-8987 | - |
dc.identifier.issn | 1421-9778 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8692 | - |
dc.description.abstract | Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear. | es |
dc.format | application/pdf | - |
dc.language.iso | eng | es |
dc.rights | Acceso Abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Cellular Physiology and Biochemistry. 2018;47(4):1509-1532 | es |
dc.subject | GENES | es |
dc.subject | AUDICION | es |
dc.subject | PROTEINAS | es |
dc.subject | SORDERA | es |
dc.subject | PERDIDA AUDITIVA | es |
dc.subject | MODIFICIACION GENETICA | es |
dc.title | Gαi proteins are indispensable for hearing | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1159/000490867 | - |
dc.identifier.pmid | 29940568 | - |
uca.disciplina | MEDICINA | - |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Beer-Hammer, Sandra. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania | es |
uca.affiliation | Fil: Lee, Sze Chim. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania | es |
uca.affiliation | Fil: Mauriac, Stephanie A. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Francia | es |
uca.affiliation | Fil: Mauriac, Stephanie A. University of Bordeaux. Neurocentre Magendie; Francia | es |
uca.affiliation | Fil: Leiss, Veronika. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania | es |
uca.affiliation | Fil: Groh, Isabel A. M. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania | es |
uca.affiliation | Fil: Novakovic, Ana. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania | es |
uca.affiliation | Fil: Piekorz, Roland P. University of Düsseldorf. Medical Faculty. Institute for Biochemistry and Molecular Biology II; Alemania | es |
uca.affiliation | Fil: Bucher, Kirsten. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania | es |
uca.affiliation | Fil: Chen, Chengfang. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania | es |
uca.affiliation | Fil: Ni, Kun. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania | es |
uca.affiliation | Fil: Singer, Wibke. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania | es |
uca.affiliation | Fil: Harasztosi, Csaba. University of Tübingen. Section of Physiological Acoustics and Communication. Tübingen Hearing Research Center. Department of Otolaryngology; Alemania | es |
uca.affiliation | Fil: Schimmang, Thomas. Universidad de Valladolid. Instituto de Biologíay Genética Molecular; España | es |
uca.affiliation | Fil: Schimmang, Thomas. Consejo Superior de Investigaciones Científicas; España | es |
uca.affiliation | Fil: Zimmermann, Ulrike. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. bMolecular Physiology of Hearing; Alemania | es |
uca.affiliation | Fil: Pfeffer, Klaus. University of Düsseldorf. Institute of Medical Microbiology and Hospital Hygiene; Alemania | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences, National Institute of Health. Neurobiology Laboratory; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Forge, Andrew. University College London. Ear Institute; Reino Unido | es |
uca.affiliation | Fil: Montcouquiol, Mireille. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Francia | es |
uca.affiliation | Fil: Montcouquiol, Mireille. University of Bordeaux. Neurocentre Magendie; Francia | es |
uca.affiliation | Fil: Knipper, Marlies. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania | es |
uca.affiliation | Fil: Nürnberg, Bernd. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania | es |
uca.affiliation | Fil: Rüttiger, Lukas. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Francia | es |
uca.version | publishedVersion | es |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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