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Título : Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits
Autor : Sonoda, Takuma 
Lee, Seul Ki 
Birnbaumer, Lutz 
Schmidt, Tiffany M. 
Fecha de publicación : 2018
Editorial : Elsevier (Cell Press)
Cita : Sonoda T, Lee SK, Birnbaumer L, Schmidt TM. Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits [en línea]. Neuron. 2018;99(4):754-767.e4. doi:10.1016/j.neuron.2018.06.032 Disponible en:
Resumen : Abstract: Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells (ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A major unanswered question is how the same photopigment, melanopsin, influences such vastly different functions. Here we show that melanopsin's role in contrast detection begins in the retina, via direct effects on M4 ipRGC (ON alpha RGC) signaling. This influence persists across an unexpectedly wide range of environmental light levels ranging from starlight to sunlight, which considerably expands the functional reach of melanopsin on visual processing. Moreover, melanopsin increases the excitability of M4 ipRGCs via closure of potassium leak channels, a previously unidentified target of the melanopsin phototransduction cascade. Strikingly, this mechanism is selective for image-forming circuits, as M1 ipRGCs (involved in non-image forming behaviors), exhibit a melanopsin-mediated decrease in excitability. Thus, melanopsin signaling is repurposed by ipRGC subtypes to shape distinct visual behaviors.
ISSN : 0896-6273
1097-4199 (online)
Disciplina: MEDICINA
DOI: 10.1016/j.neuron.2018.06.032
Derechos: Acceso Abierto
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