Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8690
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dc.contributor.authorSonoda, Takumaes
dc.contributor.authorLee, Seul Kies
dc.contributor.authorBirnbaumer, Lutzes
dc.contributor.authorSchmidt, Tiffany M.es
dc.date.accessioned2019-09-05T19:39:11Z-
dc.date.available2019-09-05T19:39:11Z-
dc.date.issued2018-
dc.identifier.citationSonoda T, Lee SK, Birnbaumer L, Schmidt TM. Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits [en línea]. Neuron. 2018;99(4):754-767.e4. doi:10.1016/j.neuron.2018.06.032 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8690es
dc.identifier.issn0896-6273-
dc.identifier.issn1097-4199 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/8690-
dc.description.abstractAbstract: Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells (ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A major unanswered question is how the same photopigment, melanopsin, influences such vastly different functions. Here we show that melanopsin's role in contrast detection begins in the retina, via direct effects on M4 ipRGC (ON alpha RGC) signaling. This influence persists across an unexpectedly wide range of environmental light levels ranging from starlight to sunlight, which considerably expands the functional reach of melanopsin on visual processing. Moreover, melanopsin increases the excitability of M4 ipRGCs via closure of potassium leak channels, a previously unidentified target of the melanopsin phototransduction cascade. Strikingly, this mechanism is selective for image-forming circuits, as M1 ipRGCs (involved in non-image forming behaviors), exhibit a melanopsin-mediated decrease in excitability. Thus, melanopsin signaling is repurposed by ipRGC subtypes to shape distinct visual behaviors.es
dc.formatapplication/pdf-
dc.language.isoenges
dc.publisherElsevier (Cell Press)es
dc.rightsAcceso Abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceNeuron. 2018;99(4):754-767.e4es
dc.subjectRETINAes
dc.subjectLUZes
dc.subjectCOMPORTAMIENTOes
dc.subjectGANGLIOSes
dc.titleMelanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuitses
dc.typeArtículoes
dc.identifier.doi10.1016/j.neuron.2018.06.032-
dc.identifier.pmid30017393-
uca.disciplinaMEDICINA-
uca.issnrd1es
uca.affiliationFil: Sonoda, Takuma. Northwestern University. Department of Neurobiology; Estados Unidoses
uca.affiliationFil: Sonoda, Takuma. Northwestern University. Northwestern University Interdepartmental Neuroscience Program; Estados Unidoses
uca.affiliationFil: Lee, Seul Ki. Northwestern University. Department of Neurobiology; Estados Unidoses
uca.affiliationFil: Birnbaumer, Lutz. National Institutes of Health. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidoses
uca.affiliationFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Schmidt, Tiffany M. Northwestern University. Department of Neurobiology; Estados Unidoses
uca.versionpublishedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Función y Farmacología de Canales Iónicos-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.orcid0000-0002-0775-8661-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
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