Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8369
Título : Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
Autor : Massari, Noelia A. 
Nicoud, Melisa Beatriz 
Sambuco, Lorena 
Cricco, Graciela P. 
Martinel Lamas, Diego J. 
Herrero Ducloux, María V. 
Blanco, Horacio 
Rivera, Elena S. 
Medina, Vanina Araceli 
Palabras clave : ONCOLOGIAMELANOMACANCER DE PIELHISTAMINATRATAMIENTO MEDICORADIACION IONIZANTE
Fecha de publicación : 2017
Editorial : Impact Journals
Cita : Massari, N. A., et al. Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation [en línea]. Oncotarget. 2017, 8 (16). doi:10.18632/oncotarget.15594. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8369
Resumen : Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical metastatic model of melanoma. Additionally, we aimed to investigate the combinatorial effect of histamine and gamma radiation on the radiobiological response of melanoma cells. Results indicate that 1205Lu metastatic melanoma cells express H4R and that histamine inhibits proliferation, in part through the stimulation of the H4R, and induces cell senescence and melanogenesis. Daily treatment with H4R agonists (1 mg/kg, sc) exhibited a significant in vivo antitumor effect and importantly, compounds reduced metastatic potential, particularly in the group treated with JNJ28610244, the H4R agonist with higher specificity. H4R is expressed in benign and malignant lesions of melanocytic lineage, highlighting the potential clinical use of histamine and H4R agonists. In addition, histamine increased radiosensitivity of melanoma cells in vitro and in vivo. We conclude that stimulation of H4R by specific ligands may represent a novel therapeutic strategy in those tumors that express this receptor. Furthermore, through increasing radiation-induced response, histamine could improve cancer radiotherapy for the treatment of melanoma.
URI : https://repositorio.uca.edu.ar/handle/123456789/8369
ISSN : 1949-2553
Disciplina: MEDICINA
DOI: 10.18632/oncotarget.15594
Derechos: Acceso Abierto
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