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Título : Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
Autor : Herrera, María Inés 
Otero Losada, Matilde 
Udovin, Lucas Daniel 
Kusnier, Carlos Federico 
Kölliker Frers, Rodolfo 
Souza, Wanderley de 
Capani, Francisco 
Fecha de publicación : 2017
Cita : Herrera, M.I., Otero Losada, M., Udoven, L.D., Kusnler, C., Kölliker Frers, R., Souza, W., Capani, F. (2017). Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model [en línea]. Neural plasticity. Disponible en:
Resumen : Abstract: Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with highmorbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunctionwith perinatal asphyxia on the basis of updated evidence froman experimental model
Disciplina: PSICOLOGIA
Derechos: Acceso Abierto
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