Please use this identifier to cite or link to this item:
https://repositorio.uca.edu.ar/handle/123456789/1666
Título : | Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis | Autor : | Rosenstein, Ruth E. Pandi Perumal, Seithikurippu R. Srinivasan, Venkataramanujan Spence, David Warren Brown, Gregory M. Cardinali, Daniel Pedro |
Palabras clave : | MELATONINA; OFTALMOLOGIA; RECEPTORES DE MELATONINA; ESTRES OXIDATIVO; OJOS; GLAUCOMA; UVEITIS; APLICACIONES TERAPEUTICAS | Fecha de publicación : | 2010 | Cita : | Rosenstein, R. E., et al. Melatonin as a therapeutic tool in ophthalmology : implication for glaucoma and uveitis [en línea]. Preprint de artículo publicado en Journal of Pineal Research. 2010, 49 (1). doi:10.1111/j.1600-079X.2010.00764.x. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1666 | Resumen : | Abstract: Several lines of evidence support the view that increased free radical generation and altered nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular diseases, such as glaucoma and uveitis. Data are discussed indicating that melatonin, being an efficient antioxidant that displays antinitridergic properties, has a promising role in the treatment of these ocular dysfunctions. Melatonin synthesis occurs in the eye of most species and melatonin receptors are localized in different ocular structures. In view of the fact that melatonin lacks significant adverse collateral effects even at high doses, the application of melatonin could potentially protect ocular tissues by effectively scavenging free radicals and excessive amounts of NO generated in the glaucomatous or uveitic eye. | URI : | https://repositorio.uca.edu.ar/handle/123456789/1666 | Disciplina: | MEDICINA | DOI: | 10.1111/j.1600-079X.2010.00764.x | Derechos: | Acceso Abierto |
Appears in Collections: | Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
melatonin-glaucoma-uveitis.pdf | 582,44 kB | Adobe PDF | View/Open |
Page view(s)
161
checked on Apr 25, 2024
Download(s)
202
checked on Apr 25, 2024
Google ScholarTM
Check
Altmetric
This item is licensed under a Creative Commons License