Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1666
Título : Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
Autor : Rosenstein, Ruth E. 
Pandi Perumal, Seithikurippu R. 
Srinivasan, Venkataramanujan 
Spence, David Warren 
Brown, Gregory M. 
Cardinali, Daniel Pedro 
Palabras clave : MELATONINAOFTALMOLOGIARECEPTORES DE MELATONINAESTRES OXIDATIVOOJOSGLAUCOMAUVEITISAPLICACIONES TERAPEUTICAS
Fecha de publicación : 2010
Cita : Rosenstein, R. E., et al. Melatonin as a therapeutic tool in ophthalmology : implication for glaucoma and uveitis [en línea]. Preprint de artículo publicado en Journal of Pineal Research. 2010, 49 (1). doi:10.1111/j.1600-079X.2010.00764.x. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1666
Resumen : Abstract: Several lines of evidence support the view that increased free radical generation and altered nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular diseases, such as glaucoma and uveitis. Data are discussed indicating that melatonin, being an efficient antioxidant that displays antinitridergic properties, has a promising role in the treatment of these ocular dysfunctions. Melatonin synthesis occurs in the eye of most species and melatonin receptors are localized in different ocular structures. In view of the fact that melatonin lacks significant adverse collateral effects even at high doses, the application of melatonin could potentially protect ocular tissues by effectively scavenging free radicals and excessive amounts of NO generated in the glaucomatous or uveitic eye.
URI : https://repositorio.uca.edu.ar/handle/123456789/1666
Disciplina: MEDICINA
DOI: 10.1111/j.1600-079X.2010.00764.x
Derechos: Acceso Abierto
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