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|Título :||An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor||Autor :||Abulafia, Carolina Andrea
Vidal, María F.
Guinjoan, Salvador M.
Cardinali, Daniel Pedro
Vigo, Daniel E.
|Palabras clave :||DETERIORO COGNITIVO LEVE; MELATONINA; ACTIGRAFIA; SUEÑO; RITMO CIRCADIANO; TRASTORNOS DEL SUEÑO||Fecha de publicación :||2023||Editorial :||Dove Press||Cita :||Abulafia, C. A. et al. An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor [en línea]. Clinical Interventions in Aging. 2023, 18. doi: 10.2147/CIA.S394749. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16425||Resumen :||Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Patients and Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake autonomic activity. Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects. Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than controls not taking melatonin (RMSSD −7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004). Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages of dementia as well as a potential protective effect of exogenous melatonin in this population.||URI :||https://repositorio.uca.edu.ar/handle/123456789/16425||ISSN :||1178-1998||Disciplina:||MEDICINA||DOI:||10.2147/CIA.S394749||Derechos:||Acceso abierto|
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