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|Título :||Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats||Autor :||Cardinali, Daniel Pedro
Scacchi Bernasconi, Pablo A.
Reyes Toso, Carlos F.
|Palabras clave :||SINDROME METABOLICO; MELATONINA; HIPERTENSION; FRUCTOSA; DISLIPIDEMIA; OBESIDAD; TOLERANCIA A LA GLUCOSA||Fecha de publicación :||2013||Editorial :||Multidisciplinary Digital Publishing Institute||Cita :||Cardinali, D. P., et al. Melatonin may curtail the metabolic syndrome : studies on initial and fully established frucose-induced metabolic syndrome in rats [en línea]. International journal of molecular sciences. 2013, 14. doi:10.3390/ijms14022502. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1639||Resumen :||Abstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases||URI :||https://repositorio.uca.edu.ar/handle/123456789/1639||ISSN :||1661-6596 (impreso)
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