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Título : Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats
Autor : Jiménez Ortega, Vanesa 
Ríos Lugo, María J. 
Cano Barquilla, Pilar 
Cardinali, Daniel Pedro 
Esquifino, Ana I. 
Fernández Mateos, María P. 
Spinedi, Eduardo J. 
Fecha de publicación : 2015
Editorial : De Gruyter
Cita : Ríos Lugo, M. J., et al. Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats [en línea]. Preprint del artículo publicado en Hormone Molecular Biology and Clinical Investigation. 2015, 21 (3). doi:10.1515/hmbci-2014-0041. Disponible en:
Resumen : Abstract: Background: Previous studies indicate that the administration of melatonin caused body weight and abdominal visceral fat reductions in rodent models of hyperadiposity. The objective of the present study performed in high-fat fed rats was to evaluate the activity of melatonin on gene expression of some medial basal hypothalamus (MBH) signals involved in feeding behavior regulation, including neuropeptide Y (NPY), proopiomelanocortin (POMC), prolactin-releasing peptide (PrRP), leptin- and insulinreceptors (R) and insulin-R substrate (IRS)-1 and -2. Blood levels of leptin and adiponectin were also measured. Methods: Adult Wistar male rats were divided into four groups (n= 16/group): (i) control diet (3 % fat); (ii) high-fat (35 %) diet; (iii) high-fat diet + melatonin; (iv) control diet + melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions: (a) tap water; (b) 25 μg/mL of melatonin. Results: After 10 weeks, the high-fat fed rats showed augmented MBH mRNA levels of NPY, leptin-R, PrRP, insulin-R, IRS-1 and IRS-2. The concomitant administration of melatonin counteracted this increase. Feeding of rats with a high-fat diet augmented expression of MBH POMC gene through an effect insensitive to melatonin treatment. The augmented levels of circulating leptin and adiponectin seen in high-fat fed rats were counteracted by melatonin as was the augmented body weight: melatonin significantly attenuated body weight increase in high-fat fed rats without affecting chow or water consumption. Melatonin augmented plasma leptin and adiponectin in control rats. Conclusions: The results indicate that an effect on gene expression of feeding behavior signals at the CNS may complement a peripheral rise of the energy expenditure produced by melatonin to decrease body weight in high-fat fed rats
ISSN : 1868-1883 (impreso)
1868-1891 (online)
Disciplina: MEDICINA
DOI: 10.1515/hmbci-2014-0041
Derechos: Acceso Abierto
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