Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/1638
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Jiménez Ortega, Vanesa | es |
dc.contributor.author | Ríos Lugo, María J. | es |
dc.contributor.author | Cano Barquilla, Pilar | es |
dc.contributor.author | Cardinali, Daniel Pedro | es |
dc.contributor.author | Esquifino, Ana I. | es |
dc.contributor.author | Fernández Mateos, María P. | es |
dc.contributor.author | Spinedi, Eduardo J. | es |
dc.date.accessioned | 2019-05-02T14:01:13Z | - |
dc.date.available | 2019-05-02T14:01:13Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Ríos Lugo, M. J., et al. Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats [en línea]. Preprint del artículo publicado en Hormone Molecular Biology and Clinical Investigation. 2015, 21 (3). doi:10.1515/hmbci-2014-0041. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1638 | es |
dc.identifier.issn | 1868-1883 (impreso) | - |
dc.identifier.issn | 1868-1891 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/1638 | - |
dc.description.abstract | Abstract: Background: Previous studies indicate that the administration of melatonin caused body weight and abdominal visceral fat reductions in rodent models of hyperadiposity. The objective of the present study performed in high-fat fed rats was to evaluate the activity of melatonin on gene expression of some medial basal hypothalamus (MBH) signals involved in feeding behavior regulation, including neuropeptide Y (NPY), proopiomelanocortin (POMC), prolactin-releasing peptide (PrRP), leptin- and insulinreceptors (R) and insulin-R substrate (IRS)-1 and -2. Blood levels of leptin and adiponectin were also measured. Methods: Adult Wistar male rats were divided into four groups (n= 16/group): (i) control diet (3 % fat); (ii) high-fat (35 %) diet; (iii) high-fat diet + melatonin; (iv) control diet + melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions: (a) tap water; (b) 25 μg/mL of melatonin. Results: After 10 weeks, the high-fat fed rats showed augmented MBH mRNA levels of NPY, leptin-R, PrRP, insulin-R, IRS-1 and IRS-2. The concomitant administration of melatonin counteracted this increase. Feeding of rats with a high-fat diet augmented expression of MBH POMC gene through an effect insensitive to melatonin treatment. The augmented levels of circulating leptin and adiponectin seen in high-fat fed rats were counteracted by melatonin as was the augmented body weight: melatonin significantly attenuated body weight increase in high-fat fed rats without affecting chow or water consumption. Melatonin augmented plasma leptin and adiponectin in control rats. Conclusions: The results indicate that an effect on gene expression of feeding behavior signals at the CNS may complement a peripheral rise of the energy expenditure produced by melatonin to decrease body weight in high-fat fed rats | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.language.iso | eng | es |
dc.publisher | De Gruyter | es |
dc.rights | Acceso Abierto | es |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | es |
dc.source | Preprint del artículo publicado en Hormone Molecular Biology and Clinical Investigation, Vol. 21, N° 3, 2015 | es |
dc.subject | MELATONINA | es |
dc.subject | GRASAS EN LA DIETA | es |
dc.subject | ALIMENTACION | es |
dc.subject | EXPRESION GENICA | es |
dc.subject | NEUROPEPTIDO Y | es |
dc.subject | PROOPIOMELANOCORTINA | es |
dc.subject | PROLACTINA | es |
dc.subject | LEPTINA | es |
dc.subject | ADIPONECTINA | es |
dc.subject | HIPOTALAMO MEDIO | es |
dc.title | Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1515/hmbci-2014-0041 | - |
uca.path | Facultad de Ciencias Médicas|Departamento de Docencia e Investigación | es |
uca.disciplina | MEDICINA | es |
uca.filename | /home/data-uca-generic/folder_generic/IIBiomedicas/melatonin-counteracts-hypothalamic/metadata.xml | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Jiménez Ortega, Vanesa. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Ríos Lugo, María J. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Cano Barquilla, Pilar. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instiuto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Cardinali, Daniel P. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Esquifino, Ana I. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Fernández Mateos, Pilar. Universidad Complutense. Facultad de Medicina. Departamento de Biología Celular; España | es |
uca.affiliation | Fil: Spinedi, Eduardo J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Spinedi, Eduardo J. Universidad Nacional de La Plata. Centro de Endocrinología Experimental y Aplicada; Argentina | es |
uca.version | submittedVersion | es |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0813-9088 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
melatonin-counteracts-hypothalamic.pdf | 420,29 kB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
206
comprobado en 27-abr-2024
Descarga(s)
344
comprobado en 27-abr-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons