Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1616
Título : Effect of a high-fat diet on 24-hour pattern in expression of prolactin and redox pathway enzymes in the rat adenohypophysis
Autor : Cano Barquilla, Pilar 
Cardinali, Daniel Pedro 
Jiménez Ortega, Vanesa 
Scacchi, Pablo 
Esquifino, Ana I. 
Palabras clave : DIETA RICA EN GRASASRITMO CIRCADIANOEXPRESION GENICAPROLACTINAOXIDO NITRICO SINTASAHEMO-OXIGENASACATALASASUPEROXIDO DISMUTASA
Fecha de publicación : 2010
Cita : Cano, P., et al. Effect of a high-fat diet on 24-hour pattern in expression of prolactin and redox pathway enzimes in the rat adenohypophysis [en línea]. The Open Obesity Journal. 2010, 2. doi:10.2174/1876823701002010001. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1616
Resumen : Abstract: The effect of a high-fat diet (35% fat) on 24-h changes in expression of prolactin and redox pathway enzyme genes was examined in the anterior pituitary of male rats. When body weight of high-fat fed rats attained values about 20- 25 % higher than controls (after 66 days of treatment) animals were sacrificed at 6 different time intervals throughout a 24-h cycle. Anterior pituitary mRNA levels were measured by real-time PCR analysis. In control rats expression of the prolactin gene peaked in anterior pituitary at early scotophase, 3 h in advance to the peak in plasma prolactin levels. In high-fat fed rats this correlation was lost. A disruption of 24-h rhythmicity of pituitary gene expression of heme oxygenase (HO)-2, Cu/Zn- superoxide dismutases (SOD), Mn-SOD, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR) was apparent in high-fat fed rats. Anterior pituitary mRNA levels for nitric oxide synthase (NOS)-2 and HO-2, Cu/Zn- and Mn- SOD and catalase augmented in high-fat fed rats, whereas those of GPx and GR decreased. The results indicate a disrupted coordination between prolactin gene expression and prolactin release in highfat fed rats that comes along with a disturbed expression of redox enzyme genes in the anterior pituitary.
URI : https://repositorio.uca.edu.ar/handle/123456789/1616
Disciplina: MEDICINA
DOI: 10.2174/1876823701002010001
Derechos: Acceso Abierto
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