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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Cano Barquilla, Pilar | es |
dc.contributor.author | Cardinali, Daniel Pedro | es |
dc.contributor.author | Jiménez Ortega, Vanesa | es |
dc.contributor.author | Scacchi, Pablo | es |
dc.contributor.author | Esquifino, Ana I. | es |
dc.date.accessioned | 2019-05-02T14:01:07Z | - |
dc.date.available | 2019-05-02T14:01:07Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Cano, P., et al. Effect of a high-fat diet on 24-hour pattern in expression of prolactin and redox pathway enzimes in the rat adenohypophysis [en línea]. The Open Obesity Journal. 2010, 2. doi:10.2174/1876823701002010001. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1616 | es |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/1616 | - |
dc.description.abstract | Abstract: The effect of a high-fat diet (35% fat) on 24-h changes in expression of prolactin and redox pathway enzyme genes was examined in the anterior pituitary of male rats. When body weight of high-fat fed rats attained values about 20- 25 % higher than controls (after 66 days of treatment) animals were sacrificed at 6 different time intervals throughout a 24-h cycle. Anterior pituitary mRNA levels were measured by real-time PCR analysis. In control rats expression of the prolactin gene peaked in anterior pituitary at early scotophase, 3 h in advance to the peak in plasma prolactin levels. In high-fat fed rats this correlation was lost. A disruption of 24-h rhythmicity of pituitary gene expression of heme oxygenase (HO)-2, Cu/Zn- superoxide dismutases (SOD), Mn-SOD, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR) was apparent in high-fat fed rats. Anterior pituitary mRNA levels for nitric oxide synthase (NOS)-2 and HO-2, Cu/Zn- and Mn- SOD and catalase augmented in high-fat fed rats, whereas those of GPx and GR decreased. The results indicate a disrupted coordination between prolactin gene expression and prolactin release in highfat fed rats that comes along with a disturbed expression of redox enzyme genes in the anterior pituitary. | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.language.iso | eng | es |
dc.rights | Acceso Abierto | es |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | es |
dc.source | The Open Obesity Journal. 2010, 2. | es |
dc.subject | DIETA RICA EN GRASAS | es |
dc.subject | RITMO CIRCADIANO | es |
dc.subject | EXPRESION GENICA | es |
dc.subject | PROLACTINA | es |
dc.subject | OXIDO NITRICO SINTASA | es |
dc.subject | HEMO-OXIGENASA | es |
dc.subject | CATALASA | es |
dc.subject | SUPEROXIDO DISMUTASA | es |
dc.title | Effect of a high-fat diet on 24-hour pattern in expression of prolactin and redox pathway enzymes in the rat adenohypophysis | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.2174/1876823701002010001 | - |
uca.path | Facultad de Ciencias Médicas|Departamento de Docencia e Investigación | es |
uca.disciplina | MEDICINA | es |
uca.filename | /home/data-uca-generic/folder_generic/IIBiomedicas/high-fat-diet-prolactin-adenohypophysis/metadata.xml | es |
uca.issnrd | 1 | es |
uca.version | publishedVersion | es |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0813-9088 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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