Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1608
Título : Therapeutic application of melatonin in mild cognitive impairment
Autor : Cardinali, Daniel Pedro 
Vigo, Daniel Eduardo 
Olivar, Natividad 
Vidal, María Florencia 
Furio, Analía M. 
Brusco, Luis I. 
Palabras clave : ENFERMEDAD DE ALZHEIMERMELATONINABENZODIAZEPINASTEST NEUROPSICOLOGICOSDETERIORO COGNITIVO LEVE
Fecha de publicación : 2012
Editorial : e-Century Publishing
Cita : Cardinali, D. P., et al. Therapeutic application of melatonin in mild cognitive impairment [en línea]. American Journal of Neurodegenerative Disease. 2012, 1 (3). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1608
Resumen : Abstract: Mild cognitive impairment (MCI) is an etiologically heterogeneous syndrome defined by cognitive impairment in advance of dementia. We previously reported in a retrospective analysis that daily 3 - 9 mg of a fast-release melatonin preparation given p. o. at bedtime for up to 3 years significantly improved cognitive and emotional performance and daily sleep/wake cycle in MCI patients. In a follow up of that study we now report data from another series of 96 MCI outpatients, 61 of who had received daily 3 - 24 mg of a fast-release melatonin preparation p. o. at bedtime for 15 to 60 months. Melatonin was given in addition to the standard medication prescribed by the attending psychiatrist. Patients treated with melatonin exhibited significantly better performance in Mini–Mental State Examination and the cognitive subscale of the Alzheimer’s disease Assessment Scale. After application of a neuropsychological battery comprising a Mattis´ test, Digit-symbol test, Trail A and B tasks and the Rey´s verbal test, better performance was found in melatonin-treated patients for every parameter tested. Abnormally high Beck Depression Inventory scores decreased in melatonin-treated patients, concomitantly with the improvement in the quality of sleep and wakefulness. The comparison of the medication profile in both groups of MCI patients indicated that 9.8% in the melatonin group received benzodiazepines vs. 62.8% in the non-melatonin group. The results further support that melatonin can be a useful add-on drug for treating MCI in a clinic environment
URI : https://repositorio.uca.edu.ar/handle/123456789/1608
ISSN : 2165-591X
Disciplina: MEDICINA
Derechos: Acceso Abierto
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