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Título : Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats
Autor : Herrera, María Inés 
Udovin, Lucas D. 
Kobiec, Tamara 
Toro Urrego, Nicolás 
Kusnier, Carlos Federico 
Kölliker Frers, Rodolfo 
Luaces, Juan P. 
Otero Losada, Matilde 
Capani, Francisco 
Fecha de publicación : 2022
Editorial : Frontiers Media
Cita : Herrera, M. I. Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats [en línea]. Frontiers in behavioral neuroscience. 2022, 16, 953157. doi: Disponible en:
Proyecto: Neuroprotección en asfixia perinatal. Una aproximación traslacional 
Resumen : Impaired gas exchange close to labor causes perinatal asphyxia (PA), a neurodevelopmental impairment factor. Palmitoylethanolamide (PEA) proved neuroprotective in experimental brain injury and neurodegeneration models. This study aimed to evaluate PEA effects on the immature-brain, i.e., early neuroprotection by PEA in an experimental PA paradigm. Newborn rats were placed in a 37◦C water bath for 19 min to induce PA. PEA 10 mg/kg, s.c., was administered within the first hour of life. Neurobehavioral responses were assessed from postnatal day 1 (P1) to postnatal day 21 (P21), recording the day of appearance of several reflexes and neurological signs. Hippocampal CA1 area ultrastructure was examined using electron microscopy. Microtubuleassociated protein 2 (MAP-2), phosphorylated high and medium molecular weight neurofilaments (pNF H/M), and glial fibrillary acidic protein (GFAP) were assessed using immunohistochemistry and Western blot at P21. Over the first 3 weeks of life, PA rats showed late gait, negative geotaxis and eye-opening onset, and delayed appearance of air-righting, auditory startle, sensory eyelid, forelimb placing, and grasp reflexes. On P21, the hippocampal CA1 area showed signs of neuronal degeneration and MAP-2 deficit. PEA treatment reduced PA-induced hippocampal damage and normalized the time of appearance of gait, air-righting, placing, and grasp reflexes. The outcome of this study might prove useful in designing intervention strategies to reduce early neurodevelopmental delay following PA...
ISSN : 1662-5153 (online)
Disciplina: PSICOLOGIA
DOI: 10.3389/fnbeh.2022.953157
Derechos: Acceso abierto
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