Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1458
Título : Melatonin, mitochondria, and the metabolic syndrome
Autor : Cardinali, Daniel Pedro 
Vigo, Daniel Eduardo 
Palabras clave : MEDICINAMELATONINADIABETESOBESIDADSINDROME METABOLICOMITOCONDRIA
Fecha de publicación : 2017
Editorial : Springer International Publishing
Cita : Cardinali, D. P., Vigo, D. E. Melatonin, mitochondria, and the metabolic syndrome [en línea]. Preprint del documento publicado en Cellular and Molecular Life Sciences. 2017, 74 (21). doi: 10.1007/s00018-017-2611-0. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1458
Resumen : Abstract: A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed.
URI : https://repositorio.uca.edu.ar/handle/123456789/1458
ISSN : 1420-682X (impreso)
1420-9071 (online)
Disciplina: MEDICINA
DOI: 10.1007/s00018-017-2611-0
Derechos: Acceso Abierto. 6 meses de embargo
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat
melatonin-mitochondria-metabolic-syndrome.jpg3,42 kBJPEGThumbnail
View/Open
melatonin-mitochondria-metabolic-syndrome.pdf1,17 MBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

218
checked on Mar 2, 2021

Download(s)

387
checked on Mar 2, 2021

Google ScholarTM

Check


Altmetric


This item is licensed under a Creative Commons License Creative Commons