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https://repositorio.uca.edu.ar/handle/123456789/1458
Título : | Melatonin, mitochondria, and the metabolic syndrome | Autor : | Cardinali, Daniel Pedro Vigo, Daniel Eduardo |
Palabras clave : | MEDICINA; MELATONINA; DIABETES; OBESIDAD; SINDROME METABOLICO; MITOCONDRIA | Fecha de publicación : | 2017 | Editorial : | Springer International Publishing | Cita : | Cardinali, D. P., Vigo, D. E. Melatonin, mitochondria, and the metabolic syndrome [en línea]. Preprint del documento publicado en Cellular and Molecular Life Sciences. 2017, 74 (21). doi: 10.1007/s00018-017-2611-0. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1458 | Resumen : | Abstract: A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed. | URI : | https://repositorio.uca.edu.ar/handle/123456789/1458 | ISSN : | 1420-682X (impreso) 1420-9071 (online) |
Disciplina: | MEDICINA | DOI: | 10.1007/s00018-017-2611-0 | Derechos: | Acceso Abierto. 6 meses de embargo |
Aparece en las colecciones: | Artículos |
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