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Título : Effects of oligoelements Se, Zn, and Mn plus Lachesis muta venom in experimental scleroderma
Autor : Crescenti, Ernesto, J. V. 
Medina, Vanina Araceli 
Sambuco, Lorena 
Cremaschi, Graciela A. 
Genaro, Ana María 
Cricco, Graciela P. 
Martín, Gabriela A. 
Valli, Eduardo 
Martinel Lamas, Diego José 
Perazzo, Juan C. 
Rivera, Elena S. 
Bergoc, Rosa M. 
Fecha de publicación : 2014
Editorial : Springer
Cita : Crescenti, E.J.V., et al. Effects of oligoelements Se, Zn, and Mn plus Lachesis muta venom in experimental scleroderma [en línea]. Biological Trace Element Research. 2014, 157 doi:10.1007/s12011-013-9876-4 Disponible en:
Resumen : Abstract: Scleroderma, sclerosis of the skin, is a severe autoimmune disease refractant to all kind of treatments. To study the in vivo effects of a combination of three oligoelements selenium (Se), zinc (Zn), and manganese (Mn) plus Lachesis muta venom (O-LM) on the bleomycin (BLM)-induced scleroderma mouse experimental model. C3H mice were randomly divided into four groups: control (phosphate-buffered saline (PBS)), O-LM, BLM, and BLM + O-LM. All administrations were performed subcutaneously into the back of mice. BLM was injected 5 days per week for three consecutive weeks and O-LM was administered simultaneously with BLM from the beginning of the experiments and lasted for 3 weeks after the final BLM or PBS injection (for O-LM and BLM + O-LM groups), when animals were sacrificed and histopathological, immunohistochemical, thiobarbituric acid reactive species (TBARS) evaluation, and autoantibodies detection were determined. O-LM significantly reduced BLM-induced enhanced dermal thickness (605 ± 47 vs. 956 ± 59 μm, P < 0.01), collagen deposition, and mast cells infiltration (43.1 ± 1.0 vs. 102 ± 14.1 mast cells, P < 0.05). O-LM administration significantly blocked BLM-induced oxidative damage and the enhanced immunoreactive fibroblasts for α-smooth muscle actin while reduced BLM-induced autoantibodies that strongly react mainly with skin and spleen. O-LM significantly reduced BLM-induced scleroderma through the modulation of antioxidant and immunological pathways.
ISSN : 1559-0720 (online)
Disciplina: MEDICINA
DOI: 10.1007/s12011-013-9876-4
Derechos: info:eu-repo/semantics/closedAccess
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