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Título: Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
Autor: Zamponi, Hernan P. 
Juarez Aguaysol, Leonardo 
Kukoc, Gabriela 
Domínguez, María Eugenia 
Pini, Belén 
Padilla, Eduardo G. 
Calvó, María 
Molina-Rangeon, Silvia Beatriz 
Guerrero, Gonzalo 
Figueredo Aguiar, Mariana 
Fumagalli, Emiliano 
Yécora, Agustín 
Brugha, Traolach S. 
Seshadri, Sudha 
Snyder, Heather M. 
Erausquin, Gabriel A. de 
Gonzalez Aleman, Gabriela 
Palabras clave: COVID-19SARS-CoV-2DETERIORO COGNITIVOADULTOS MAYORESDISFUNCION OLFATORIAANOSMIA PERSISTENTE
Fecha de publicación: 2021
Editorial: John Wiley & Sons
Cita: Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711
Resumen: Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia.
Cobertura Espacial: Argentina
URI: https://repositorio.uca.edu.ar/handle/123456789/13711
ISSN: 1552-5279
Disciplina: PSICOLOGIA
DOI: 10.1002/alz.057897
Derechos: Acceso abierto
Fuente: Alzheimer y dementia Vol.17, S6, e057897, 2021
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