Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/13711
Título: | Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina | Autor: | Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina-Rangeon, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Gonzalez Aleman, Gabriela |
Palabras clave: | COVID-19; SARS-CoV-2; DETERIORO COGNITIVO; ADULTOS MAYORES; DISFUNCION OLFATORIA; ANOSMIA PERSISTENTE | Fecha de publicación: | 2021 | Editorial: | John Wiley & Sons | Cita: | Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711 | Resumen: | Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia. | Cobertura Espacial: | Argentina | URI: | https://repositorio.uca.edu.ar/handle/123456789/13711 | ISSN: | 1552-5279 | Disciplina: | PSICOLOGIA | DOI: | 10.1002/alz.057897 | Derechos: | Acceso abierto | Fuente: | Alzheimer y dementia Vol.17, S6, e057897, 2021 |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
olfactory-dysfunction-chronic.pdf | 756,73 kB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
142
comprobado en 27-abr-2024
Descarga(s)
73
comprobado en 27-abr-2024
Google ScholarTM
Ver en Google Scholar
Altmetric
Este ítem está sujeto a una Licencia Creative Commons