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Título : | How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease? | Autor : | Rossi, Malco Damián Pérez Lloret, Santiago Merello, Marcelo |
Palabras clave : | ENFERMEDAD DE PARKINSON; DIAGNOSTICO MÉDICO; MEDICINA CLINICA; TRASTORNOS DEL MOVIMIENTO; TRATAMIENTO FARMACOLOGICO | Fecha de publicación : | 2021 | Editorial : | Elsevier | Cita : | Rossi, M. D., Pérez Lloret, S., Merello, M. How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease? [en línea]. Parkinsonism & Related Disorders. 2021, 92. doi:10.1016/j.parkreldis.2021.10.016. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/12860 | Resumen : | Introduction: The implementation of accepted clinical diagnostic criteria has improved the accuracy of a clinical diagnosis of Parkinson’s disease (PD). Time frames of 3 to 10 years have been empirically proposed to reach a diagnosis of clinically established PD. Methods: We explored the time to a Final Clinical Diagnosis (FCD) and the factors that predict faster diagnoses in patients presenting with parkinsonism and/or tremor between 2009 and 2015 at our tertiary center. All patients underwent a standardized workout process to reach a FCD, which included an acute levodopa challenge (LDC) after the first visit. Results: Among the 326 patients included, 215 (66%) received a FCD within the first six months after the LDC. A FCD was reached in 95% and 100% of patients in 33 and 108 months, respectively. PD was the FCD in 196 patients (60.1%). The FCD was reached faster in patients with a positive response to levodopa and when the FCD was PD. Conclusion: The time needed to reach a final diagnosis in the clinical setting was 2.75 years in 95% of patients presenting initially with parkinsonism and/or tremor. Patients with positive responses to levodopa at the LDC, benefited from shorter delays until the FCD. | URI : | https://repositorio.uca.edu.ar/handle/123456789/12860 | ISSN : | 1353-8020 (impreso) | Disciplina: | MEDICINA | DOI: | 10.1016/j.parkreldis.2021.10.016 | Derechos: | Acceso abierto. 12 meses de embargo |
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