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Título : | Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis | Autor : | Kölliker Frers, Rodolfo Otero Losada, Matilde Kobiec, Tamara Herrera, María Inés Udovin, Lucas Daniel Kusnier, Carlos Federico Capani, Francisco |
Palabras clave : | PSORIASIS; ENFERMEDADES AUTOINMUNES; INTERLEUKIN-1 | Fecha de publicación : | 2021 | Editorial : | Hidawi | Cita : | Kölliker Frers, R., et al. Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis [en línea]. Mediators of Inflammation. 2021 doi:10.1155/2021/2503378 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/12546 | Proyecto: | Neuroprotección en asfixia perinatal. Una aproximación traslacional | Resumen : | Abstract: Autoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature. Failure in regulatory mechanisms triggers a complex network of dynamic relationships between innate and adaptive immunity, leading to coexistent autoinflammatory and autoimmune processes. Sustained exposure to a trigger or a genetic alteration at the level of the receptors of the natural immune system may lead to abnormal activation of the innate immune system, adaptive system activation, loss of self-tolerance, and systemic inflammation. The IL-1 family members critically activate and regulate innate and adaptive immune responses’ diversity and plasticity in autoimmune and/or autoinflammatory conditions. The IL-23/IL-17 axis is key in the communication between innate immunity (IL-23-producing myeloid cells) and adaptive immunity (Th17- and IL-17-expressing CD8+ T cells). In psoriasis, these cytokines are decisive to the different clinical presentations, whether as plaque psoriasis (psoriasis vulgaris), generalized pustular psoriasis (pustular psoriasis), or mixed forms. These forms reflect a gradient between autoimmune pathophysiology with predominant adaptive immune response and autoinflammatory pathophysiology with predominant innate immune response. | URI : | https://repositorio.uca.edu.ar/handle/123456789/12546 | ISSN : | 0962-9351 (Print) 1466-1861 (Online |
Disciplina: | PSICOLOGIA | DOI: | 10.1155/2021/2503378 | Derechos: | Acceso abierto |
Appears in Collections: | Artículos |
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