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Título : Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis
Autor : Kölliker Frers, Rodolfo 
Otero Losada, Matilde 
Kobiec, Tamara 
Herrera, María Inés 
Udovin, Lucas Daniel 
Kusnier, Carlos Federico 
Capani, Francisco 
Fecha de publicación : 2021
Editorial : Hidawi
Cita : Kölliker Frers, R., et al. Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis [en línea]. Mediators of Inflammation. 2021 doi:10.1155/2021/2503378 Disponible en:
Proyecto: Neuroprotección en asfixia perinatal. Una aproximación traslacional 
Resumen : Abstract: Autoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature. Failure in regulatory mechanisms triggers a complex network of dynamic relationships between innate and adaptive immunity, leading to coexistent autoinflammatory and autoimmune processes. Sustained exposure to a trigger or a genetic alteration at the level of the receptors of the natural immune system may lead to abnormal activation of the innate immune system, adaptive system activation, loss of self-tolerance, and systemic inflammation. The IL-1 family members critically activate and regulate innate and adaptive immune responses’ diversity and plasticity in autoimmune and/or autoinflammatory conditions. The IL-23/IL-17 axis is key in the communication between innate immunity (IL-23-producing myeloid cells) and adaptive immunity (Th17- and IL-17-expressing CD8+ T cells). In psoriasis, these cytokines are decisive to the different clinical presentations, whether as plaque psoriasis (psoriasis vulgaris), generalized pustular psoriasis (pustular psoriasis), or mixed forms. These forms reflect a gradient between autoimmune pathophysiology with predominant adaptive immune response and autoinflammatory pathophysiology with predominant innate immune response.
ISSN : 0962-9351 (Print)
1466-1861 (Online
Disciplina: PSICOLOGIA
DOI: 10.1155/2021/2503378
Derechos: Acceso abierto
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