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Título : Neuroinflammation : an integrating overview of reactive-neuroimmune cell interactions in health and disease
Autor : Kölliker Frers, Rodolfo 
Udovin, Lucas Daniel 
Otero Losada, Matilde 
Kobiec, Tamara 
Palacios, Jorge 
Razzitte, Gabriela 
Capani, Francisco 
Herrera, María Inés 
Fecha de publicación : 2021
Editorial : Hindawi
Cita : Kölliker-Frers, R., et al. Neuroinflammation : an integrating overview of reactive-neuroimmune cell interactions in health and disease [en línea]. Mediators of Inflammation. 2021 doi:10.1155/2021/9999146 Disponible en:
Resumen : Abstract: The concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or exogenous. Neurological diseases, whether traumatic, neoplastic, ischemic, metabolic, toxic, infectious, autoimmune, developmental, or degenerative, involve direct and indirect immune-related neuroinflammation. Brain infiltrates of the innate and adaptive immune system cells appear in response to an infective or otherwise noxious agent and produce inflammatory mediators. Mediators of inflammation include local and recruited cells and signals. Processes derived from extrinsic and intrinsic CNS diseases also elicit the CNS inflammatory response. A deeper understanding of immune-related inflammation in health and disease is necessary to find potential therapeutic targets for preventing or reducing CNS damage. This review is aimed at discussing the innate and adaptive immune system functions and their roles in regulating brain cell responses in disease and homeostasis maintenance.
ISSN : 0962-9351
1466-1861 (online)
Disciplina: PSICOLOGIA
DOI: 10.1155/2021/9999146
Derechos: Acceso abierto
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