Please use this identifier to cite or link to this item:
Título : Falls risk, circadian rhythms and melatonin : current perspectives
Autor : Goswami, Nandu 
Abulafia, Carolina Andrea 
Vigo, Daniel Eduardo 
Moser, Maximilian 
Cornelissen, Germaine 
Cardinali, Daniel Pedro 
Fecha de publicación : 2020
Editorial : Dove Medical Press
Cita : Goswami, N., Abulafia, C. A., Vigo, D. E., Moser, M., Cornelissen, G., Cardinali, D. P. Falls risk, circadian rhythms and melatonin : current perspectives [en línea]. Clinical Interventions in Aging. 2020, 15. Doi: 10.2147/CIA.S283342. Disponible en:
Resumen : Abstract: Aging is associated with weakening of the circadian system. The circadian amplitude of most physiological variables is reduced, while the circadian phase becomes more labile and tends to occur earlier with advancing age. As the incidence of falls in older persons could follow circadian variations, a better understanding of conditions in which falls occur can lead to the implementation of countermeasures (such as adjusting the scheduling of hospital staff, or changing the timing of anti-hypertensive medication if falls are related to undesirable circadian patterns of blood pressure and/or heart rate). This includes knowing the times of the day, days of the week, and times of the year when falls are more likely to occur at home or in the hospital. Additionally, the links between aging processes and factors associated with an increased risk of developing autonomic dysfunction are well established. A strong association between heart rate variability indexes and aging has been shown. Circadian rhythms of autonomous nervous system activity may play important role for maintenance of orthostatic tolerance. Whether one is concerned with disease prediction and prevention or maintenance of healthy aging, the study of circadian rhythms and the broader time structure underlying physiopathology is helpful in terms of screening, early diagnosis and prognosis, as well as the timely institution of prophylactic and/or palliative/ curative treatment. Timing the administration of such treatment as a function of circadian (and other) rhythms also could lead to reduction of falls in older persons.
ISSN : 1178-1998 (impreso)
1176-9092 (on line)
Disciplina: MEDICINA
DOI: 10.2147/CIA.S283342
Derechos: Acceso abierto
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat
falls-risk-circadian-rhythms-melatonin.pdf1,36 MBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Dec 7, 2023


checked on Dec 7, 2023

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons