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Título : The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene
Autor : Kobiec, Tamara 
Otero Losada, Matilde 
Chevalier, Guenson 
Udovin, Lucas Daniel 
Bordet, Sofía 
Menéndez Maissonave, Camila Belén 
Capani, Francisco 
Pérez Lloret, Santiago 
Fecha de publicación : 2021
Editorial : Frontiers
Cita : Kobiec T., Otero Losada M., Chevalier G. , Udovin L. D. , Bordet S. , Menéndez-Maissonave C. B., Capani F., Pérez Lloret S. The renin–angiotensin system modulates dopaminergic neurotransmission : A new player on the scene [en línea]. Frontiers in Synaptic Neuroscience. 2021,13. Doi: 10.3389/fnsyn.2021.638519. Disponible en:
Proyecto: Neuroprotección en asfixia perinatal. Una aproximación traslacional 
Resumen : Abstract: Parkinson’s disease (PD) is an extrapyramidal disorder characterized by neuronal degeneration in several regions of the peripheral and central nervous systems. It is the second most frequent neurodegenerative disease after Alzheimer’s. It has become a major health problem, affecting 1% of the world population over 60 years old and 3% of people beyond 80 years. The main histological findings are intracellular Lewy bodies composed of misfolded a-synuclein protein aggregates and loss of dopaminergic neurons in the central nervous system. Neuroinflammation, apoptosis, mitochondrial dysfunction, altered calcium homeostasis, abnormal protein degradation, and synaptic pathobiology have been put forward as mechanisms leading to cell death, a-synuclein deposition, or both. A progressive loss of dopaminergic neurons in the substantia nigra late in the neurodegeneration leads to developing motor symptoms like bradykinesia, tremor, and rigidity. The renin–angiotensin system (RAS), which is involved in regulating blood pressure and body fluid balance, also plays other important functions in the brain. The RAS is involved in the autocrine and paracrine regulation of the nigrostriatal dopaminergic synapses. Dopamine depletion, as in PD, increases angiotensin II expression, which stimulates or inhibits dopamine synthesis and is released via AT1 or AT2 receptors.
ISSN : 1663-3563 (On line)
Disciplina: PSICOLOGIA
DOI: 10.3389/fnsyn.2021.638519
Derechos: Acceso abierto
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