Correlative structural, biochemical and behavioral study in neuroprotection with palmitoylehanolamide after perinatal asphyxia in the immature brain

Abstract

Abstract: Perinatal asphyxia (PA) is an obstetric complication associated with an impaired gas exchange. Diminish in the oxygen levels prompted short and long-term alterations in synapses and related structures that are related to neuronal dysfunction and death. This serious health problem could lead to neonatal mortality and continues to be a determinant of several neurodevelopmental disorders. The lack of knowledge about the proper neuroprotective agents prompted us to investigate the role of Palmitoylethanolamide (PEA) in the experimental treatment of PA. This natural occurring amide has exerted protective effects in several models of brain injury and neurodegeneration.