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Título : Synaptoprotection in perinatal asphyxia: an experimental approach
Autor : Herrera, María Inés 
Kobiec, Tamara 
Kölliker Frers, Rodolfo 
Otero Losada, Matilde 
Capani, Francisco 
Fecha de publicación : 2020
Editorial : Frontiers
Cita : Herrera, M.I., Kobiec, T., Kölliker-Frers, R., Otero-Losada, M., Capani, F. Synaptoprotection in perinatal asphyxia: an experimental approach [en línea]. Frontiers in Synaptic Neuroscience. 2020, 12 (35). Disponible en:
Resumen : Perinatal asphyxia (PA) is an obstetric complication occurring when the oxygen supply to the newborn is temporally interrupted. This health problem is associated with high morbimortality in term and preterm neonates. It severely affects the brain structure and function, involving cortical, hippocampal, and striatal loss of neurons. Nearly 25% of PA survivor newborns develop several neurodevelopmental disabilities. Behavioral alterations, as well as the morphological and biochemical pathways involved in PA pathophysiology, have been studied using an animal model that resembles intrauterine asphyxia. Experimental evidence shows that PA induces synaptic derangement. Then, synaptic dysfunction embodies a putative target for neuroprotective strategies. Over the last years, therapeutic hypothermia (TH), the only treatment available, has shown positive results in the clinic. Several pharmacological agents are being tested in experimental or clinical trial studies to prevent synaptopathy. Preservation of the synaptic structure and function, i.e., “synaptoprotection,” makes up a promising challenge for reducing incidental neurodevelopmental disorders associated with PA. Accordingly, here, we summarize and review the findings obtained from the referred experimental model and propose a renewed overview in the field.
ISSN : 1663-3563
Disciplina: PSICOLOGIA
DOI: 10.3389/fnsyn.2020.00035
Derechos: Acceso abierto
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