Please use this identifier to cite or link to this item:
https://repositorio.uca.edu.ar/handle/123456789/9738
Título : | Melatonin as a chronobiotic/cytoprotector : its role in healthy aging | Autor : | Cardinali, Daniel Pedro | Palabras clave : | MELATONINA; ENVEJECIMIENTO; SUEÑO; INFLAMACION; ENFERMEDAD DE ALZHEIMER | Fecha de publicación : | 2019 | Editorial : | Taylor & Francis | Cita : | Cardinali, D.P. Melatonin as a chronobiotic/cytoprotector : its role in healthy aging [en línea]. Biological Rhythm Research. 2019, 50(1). doi:10.1080/09291016.2018.1491200 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9738 | Resumen : | Abstract: Preservation of sleep, a proper nutrition and adequate physical exercise are key elements for healthy aging. Aging causes sleep alterations, and in turn, sleep disturbances lead to numerous pathophysiological changes that accelerates the aging process. In the central nervous system, sleep loss impairs the clearance of waste molecules like amyloid-β or tau peptides. Melatonin, a molecule of unusual phylogenetic conservation present in all known aerobic organisms, is effective both as a chronobiotic and a cytoprotective agent to maintain a healthy aging. The late afternoon increase of melatonin “opens the sleep doors” every night and its therapeutic use to preserve slow wave sleep has been demonstrated. Melatonin reverses inflammaging via prevention of insulin resistance, suppression of inflammation and down regulation of proinflammatory cytokines. Melatonin increases the expression of α- and γ-secretase and decreases β-secretase expression. It also inhibits tau phosphorylation. Clinical data support the efficacy of melatonin to treat Alzheimer’s disease, particularly at the early stages of disease. From animal studies the cytoprotective effects of melatonin need high doses to become apparent (i.e. in the 40–100 mg/day range). The potentiality of melatonin as a nutraceutical is discussed. | URI : | https://repositorio.uca.edu.ar/handle/123456789/9738 | ISSN : | 0929-1016 (impreso) 1744-4179 (online) |
Disciplina: | MEDICINA | DOI: | 10.1080/09291016.2018.1491200 | Derechos: | Acceso abierto |
Appears in Collections: | Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
melatonin-chronobiotic-cytoprotector.pdf | 374,12 kB | Adobe PDF | View/Open |
Page view(s)
133
checked on Apr 30, 2024
Download(s)
603
checked on Apr 30, 2024
Google ScholarTM
Check
Altmetric
This item is licensed under a Creative Commons License