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https://repositorio.uca.edu.ar/handle/123456789/9737
Título : | The chloride anion as a signalling effector | Autor : | Valdivieso, Ángel Gabriel Santa Coloma, Tomás Antonio |
Palabras clave : | TRANSDUCCION DE SEÑAL; CFTR; ANION CLORURO; INFLAMACION; ESTRES OXIDATIVO; SEÑALIZACION INTRACELULAR | Fecha de publicación : | 2019 | Editorial : | Wiley | Cita : | Valdivieso, A.G., Santa Coloma, T.A. The chloride anion as a signalling effector [en línea]. Biological Reviews. 2019, 94(5). doi:10.1111/brv.12536 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9737 | Resumen : | Abstract: The specific role of the chloride anion (Cl- ) as a signalling effector or second messenger has been increasingly recognized in recent years. It could represent a key factor in the regulation of cellular homeostasis. Changes in intracellular Cl- concentration affect diverse cellular functions such as gene and protein expression and activities, post-translational modifications of proteins, cellular volume, cell cycle, cell proliferation and differentiation, membrane potential, reactive oxygen species levels, and intracellular/extracellular pH. Cl- also modulates functions in different organelles, including endosomes, phagosomes, lysosomes, endoplasmic reticulum, and mitochondria. A better knowledge of Cl- signalling could help in understanding the molecular and metabolic changes seen in pathologies with altered Cl- transport or under physiological conditions. Here we review relevant evidence supporting the role of Cl- as a signalling effector. | URI : | https://repositorio.uca.edu.ar/handle/123456789/9737 | ISSN : | 1464-7931 (impreso) 1469-185X (online) |
Disciplina: | MEDICINA | DOI: | 10.1111/brv.12536 | Derechos: | Acceso abierto. 12 meses de embargo |
Aparece en las colecciones: | Artículos |
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