Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8769
Título : IL-17 and IFN-γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease
Autor : Jurado, Javier O. 
Pasquinelli, Virginia 
Álvarez, Ivana B. 
Peña, Delfina 
Rovetta, Ana I. 
Tateosian, Nancy L. 
Romeo, Horacio 
Musella, Rosa M. 
Palmero, Domingo 
Chuluyán, H. Eduardo 
García, Verónica E. 
Palabras clave : TUBERCULOSISENFERMEDADES INFECCIOSASLINFOCITOSCITOCINASCELULAS T
Fecha de publicación : 2012
Editorial : Society for Leukocyte Biology
Cita : Jurado JO, Pasquinelli V, Alvarez IB, et al. IL-17 and IFN-γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease. J Leukoc Biol. 2012;91(6):991–1002. doi:10.1189/jlb.1211619. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8769
Resumen : Abstract: Th1 lymphocytes are crucial in the immune response against Mycobacterium tuberculosis. Nevertheless, IFN-γ alone is not sufficient in the complete eradication of the bacteria, suggesting that other cytokines might be required for pathogen removal. Th17 cells have been associated with M. tuberculosis infection, but the role of IL-17-producing cells in human TB remains to be understood. Therefore, we investigated the induction and regulation of IFN-γ and IL-17 during the active disease. TB patients were classified as High and Low Responder individuals according to their T cell responses against the antigen, and cytokine expression upon M. tuberculosis stimulation was investigated in peripheral blood and pleural fluid. Afterwards, the potential correlation among the proportions of cytokine-producing cells and clinical parameters was analyzed. In TB patients, M. tuberculosis induced IFN-γ and IL-17, but in comparison with BCG-vaccinated healthy donors, IFN-γ results were reduced significantly, and IL-17 was markedly augmented. Moreover, the main source of IL-17 was represented by CD4(+)IFN-γ(+)IL-17(+) lymphocytes, a Th1/Th17 subset regulated by IFN-γ. Interestingly, the ratio of antigen-expanded CD4(+)IFN-γ(+)IL-17(+) lymphocytes, in peripheral blood and pleural fluid from TB patients, was correlated directly with clinical parameters associated with disease severity. Indeed, the highest proportion of CD4(+)IFN-γ(+)IL-17(+) cells was detected in Low Responder TB patients, individuals displaying severe pulmonary lesions, and longest length of disease evolution. Taken together, the present findings suggest that analysis of the expansion of CD4(+)IFN-γ(+)IL-17(+) T lymphocytes in peripheral blood of TB patients might be used as an indicator of the clinical outcome in active TB.
URI : https://repositorio.uca.edu.ar/handle/123456789/8769
ISSN : 1938-3673 (online)
Disciplina: MEDICINA
DOI: 10.1189/jlb.1211619
Derechos: Acceso abierto
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