Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/8721
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Chaudhuri, Pinaki | es |
dc.contributor.author | Rosenbaum, Michael A. | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Graham, Linda M. | es |
dc.date.accessioned | 2019-09-10T22:29:09Z | - |
dc.date.available | 2019-09-10T22:29:09Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Chaudhuri P, Rosenbaum MA, Birnbaumer L, Graham LM. Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization [en línea]. American Journal of Physiology-Cell Physiology. 2017;313(5):C541-C555. doi:10.1152/ajpcell.00028.2017 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8721 | es |
dc.identifier.issn | 0363-6143 | - |
dc.identifier.issn | 1522-1563 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8721 | - |
dc.description.abstract | Abstract: Lipid oxidation products, including lysophosphatidylcholine (lysoPC), activate canonical transient receptor potential 6 (TRPC6) channels, and the subsequent increase in intracellular Ca2+ leads to TRPC5 activation. The goal of this study is to elucidate the steps in the pathway between TRPC6 activation and TRPC5 externalization. Following TRPC6 activation by lysoPC, extracellular regulated kinase (ERK) is phosphorylated. This leads to phosphorylation of p47phox and subsequent NADPH oxidase activation with increased production of reactive oxygen species. ERK activation requires TRPC6 opening and influx of Ca2+ as evidenced by the failure of lysoPC to induce ERK phosphorylation in TRPC6-/- endothelial cells. ERK siRNA blocks the lysoPC-induced activation of NADPH oxidase, demonstrating that ERK activation is upstream of NADPH oxidase. The reactive oxygen species produced by NADPH oxidase promote myosin light chain kinase (MLCK) activation with phosphorylation of MLC and TRPC5 externalization. Downregulation of ERK, NADPH oxidase, or MLCK with the relevant siRNA prevents TRPC5 externalization. Blocking MLCK activation prevents the prolonged rise in intracellular calcium levels and preserves endothelial migration in the presence of lysoPC. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Physiological Society | es |
dc.rights | Acceso Abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | American Journal of Physiology-Cell Physiology. 2017;313(5):C541-C555 | es |
dc.subject | CLACIO | es |
dc.subject | ENDOTELIO | es |
dc.subject | PROTEINAS | es |
dc.subject | GENES | es |
dc.title | Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1152/ajpcell.00028.2017 | - |
dc.identifier.pmid | 28835433 | - |
uca.disciplina | MEDICINA | - |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Chaudhuri, Pinaki. Cleveland Clinic. Department of Biomedical Engineering; Estados Unidos | es |
uca.affiliation | Fil: Rosenbaum, Michael A. Louis Stokes Cleveland Veterans Affairs Medical Center. Surgical Service; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Research Triangle Park. Neurobiology Laboratory; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Graham, Linda M. Cleveland Clinic. Department of Biomedical Engineering; Estados Unidos | es |
uca.affiliation | Fil: Graham, Linda M. Cleveland Clinic. Department of Vascular Surgery; Estados Unidos | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
integration-tprc6-and-nadph.pdf | 4,1 MB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
159
comprobado en 27-sep-2024
Descarga(s)
156
comprobado en 27-sep-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons