Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8682
Título : Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
Autor : Trouillet, Anne-Charlotte 
Keller, Matthieu 
Weiss, Jan 
Leinders-Zufall, Trese 
Birnbaumer, Lutz 
Zufall, Frank 
Chamero, Pablo 
Palabras clave : TERRITORIALIDADAGRESIVIDADPROTEINASCOMPORTAMIENTOSISTEMA LIMBICO
Fecha de publicación : 2019
Editorial : National Academy of Sciences
Cita : Trouillet A-C, Keller M, Weiss J, et al. Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice [en línea]. Proceedings of the National Academy of Sciences. 2019;116(11):5135-5143. doi:10.1073/pnas.1821492116 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8682
Resumen : Abstract: Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male-male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male-male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infant-directed aggression and decreased activity in MeA neurons during male-infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein α-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2+ VSNs and the brain circuits activated by these neurons play a central role in orchestrating and balancing territorial and infant-directed aggression of male mice through bidirectional activation and inhibition of different targets in the limbic system.
URI : https://repositorio.uca.edu.ar/handle/123456789/8682
ISSN : 0027-8424 (print)
1091-6490 (online)
Disciplina: MEDICINA
DOI: 10.1073/pnas.1821492116
Derechos: Acceso Abierto
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