Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/8680
Título : Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
Autor : Cha, Hye Lim 
Choi, Jung-Mi 
Oh, Huy-Hyen 
Bashyal, Narayan 
Kim, Sung-Soo 
Birnbaumer, Lutz 
Suh-Kim, Haeyoung 
Palabras clave : SISTEMA NERVIOSO CENTRALCEREBELOPROTEINASHIPOPLASIA
Fecha de publicación : 2019
Editorial : BMC
Cita : Cha HL, Choi J-M, Oh H-H, et al. Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice [en línea]. Molecular Brain. 2019;12(1):57. doi:10.1186/s13041-019-0477-9 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8680
Resumen : Abtract: Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deleting its gene, Gnao. We performed a histological analysis with cerebellar sections of adult mice by cresyl violet- and immunostaining. Global deletion of Gnao induced cerebellar hypoplasia, reduced arborization of Purkinje cell dendrites, and atrophied Purkinje cell dendritic spines and the terminal boutons of climbing fibers from the inferior olivary nucleus. These results indicate that Go-mediated signaling pathway regulates maturation of presynaptic parallel fibers from granule cells and climbing fibers during the cerebellar cortical development.
URI : https://repositorio.uca.edu.ar/handle/123456789/8680
ISSN : 1756-6606
Disciplina: MEDICINA
DOI: 10.1186/s13041-019-0477-9
Derechos: Acceso Abierto
Aparece en las colecciones: Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato
deletion-of-the-a-subunit.pdf15,35 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro Dublin Core completo del ítem

Visualizaciones de página(s)

159
comprobado en 30-abr-2024

Descarga(s)

164
comprobado en 30-abr-2024

Google ScholarTM

Consultar


Altmetric


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons