Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8680
Título : Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
Autor : Cha, Hye Lim 
Choi, Jung-Mi 
Oh, Huy-Hyen 
Bashyal, Narayan 
Kim, Sung-Soo 
Birnbaumer, Lutz 
Suh-Kim, Haeyoung 
Palabras clave : SISTEMA NERVIOSO CENTRALCEREBELOPROTEINASHIPOPLASIA
Fecha de publicación : 2019
Editorial : BMC
Cita : Cha HL, Choi J-M, Oh H-H, et al. Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice [en línea]. Molecular Brain. 2019;12(1):57. doi:10.1186/s13041-019-0477-9 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8680
Resumen : Abtract: Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deleting its gene, Gnao. We performed a histological analysis with cerebellar sections of adult mice by cresyl violet- and immunostaining. Global deletion of Gnao induced cerebellar hypoplasia, reduced arborization of Purkinje cell dendrites, and atrophied Purkinje cell dendritic spines and the terminal boutons of climbing fibers from the inferior olivary nucleus. These results indicate that Go-mediated signaling pathway regulates maturation of presynaptic parallel fibers from granule cells and climbing fibers during the cerebellar cortical development.
URI : https://repositorio.uca.edu.ar/handle/123456789/8680
ISSN : 1756-6606
Disciplina: MEDICINA
DOI: 10.1186/s13041-019-0477-9
Derechos: Acceso Abierto
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat
deletion-of-the-a-subunit.pdf15,35 MBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

57
checked on Feb 26, 2021

Download(s)

61
checked on Feb 26, 2021

Google ScholarTM

Check


Altmetric


This item is licensed under a Creative Commons License Creative Commons