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Título : Immunomodulatory role of histamine H4 receptor in breast cancer
Autor : Sterle, Helena A. 
Nicoud, Melisa Beatriz 
Massari, Noelia A. 
Táquez Delgado, Mónica Alejandra 
Herrero Ducloux, María V. 
Cremaschi, Graciela A. 
Medina, Vanina Araceli 
Fecha de publicación : 2019
Editorial : Springer
Cita : Sterle HA, Nicoud MB, Massari NA, et al. Immunomodulatory role of histamine H4 receptor in breast cancer [en linea]. British Journal of Cancer 2019;120(1):128-138. doi:10.1038/s41416-018-0173-z Registro en:
Resumen : BACKGROUND: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R in antitumour immunity in a model of triple-negative breast cancer. METHODS: We evaluated growth parameters, histological characteristics and the composition of tumour, splenic and tumour draining lymph node (TDLN) immune subsets, in a syngeneic model, developed orthotopically with 4T1 cells in H4R knockout (H4R-KO) and wild-type mice. RESULTS: Mice lacking H4R show reduced tumour size and weight, decreased number of lung metastases and percentage of CD4+ tumour-infiltrating T cells, while exhibiting increased infiltration of NK cells and CD19+ lymphocytes. Likewise, TDLN of H4R-KO mice show decreased CD4+ T cells and T regulatory cells (CD4+CD25+FoxP3+), and increased percentages of NK cells. Finally, H4R-deficient mice show decreased Tregs in spleens and non-draining lymph nodes, and a negative correlation between tumour weight and the percentages of CD4+, CD19+ and NK splenic cells, suggesting that H4R also regulates antitumour immunity at a systemic level. CONCLUSIONS: This is the first report that demonstrates the participation of H4R in antitumour immunity, suggesting that H4R could be a target for cancer treatment.
ISSN : 0007-0920 (print)
1532-1827 (online)
Disciplina: MEDICINA
DOI: 10.1038/s41416-018-0173-z
Derechos: Acceso Abierto. 6 meses de embargo
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