Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/6220
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dc.contributor.authorHerrera, María Inéses
dc.contributor.authorUdovin, Lucas Danieles
dc.contributor.authorToro-Urrego, Nicoláses
dc.contributor.authorKusnier, Carloses
dc.contributor.authorLuaces, Juan P.es
dc.contributor.authorCapani, Franciscoes
dc.date.accessioned2019-06-12T01:38:52Z-
dc.date.available2019-06-12T01:38:52Z-
dc.date.issued2018-
dc.identifier.citationHerrera, M. I., Udovin, L. D., Toro-Urrego, N., Kusnier, C. F., Luaces, J. P., y Capani, F. (2018). Palmitoylethanolamide ameliorates hippocampal damage and behavioral dysfunction after perinatal asphyxia in the immature rat brain [en línea] Frontiers in Neuroscience, 12:145. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/6220es
dc.identifier.issn1662-453X-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/6220-
dc.description.abstractAbstract: Perinatal asphyxia (PA) is an obstetric complication associated with an impaired gas exchange. This health problem continues to be a determinant of neonatal mortality and neurodevelopmental disorders. Palmitoylethanolamide (PEA) has exerted neuroprotection in several models of brain injury and neurodegeneration. We aimed at evaluating the potential neuroprotective role of PEA in an experimental model, which induces PA in the immature rat brain. PA was induced by placing Sprague Dawley newborn rats in a water bath at 37°C for 19 min. Once their physiological conditions improved, they were given to surrogate mothers that had delivered normally within the last 24 h. The control group was represented by non-fostered vaginally delivered pups, mimicking the clinical situation. Treatment with PEA (10 mg/kg) was administered within the first hour of life. Modifications in the hippocampus were analyzed with conventional electron microscopy, immunohistochemistry (for NeuN, pNF-H/M, MAP-2, and GFAP) and western blot (for pNF H/M, MAP-2, and GFAP). Behavior was also studied throughout Open Field (OF) Test, Passive Avoidance (PA) Task and Elevated Plus Maze (EPM) Test. After 1 month of the PA insult, we observed neuronal nucleus degeneration in CA1 using electron microscopy. Immunohistochemistry revealed a significant increase in pNF-H/M and decrease in MAP-2 in CA1 reactive area. These changes were also observed when analyzing the level of expression of these markers by western blot. Vertical exploration impairments and anxiety-related behaviors were encountered in the OF and EPM tests. PEA treatment attenuated PA-induced hippocampal damage and its corresponding behavioral alterations. These results contribute to the elucidation of PEA neuroprotective role after PA and the future establishment of therapeutic strategies for the developing brain.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.rightsAcceso Abiertoes
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/es
dc.sourceFrontiers in Neuroscience, 12:145, 2018es
dc.subjectCOMPORTAMIENTOes
dc.subjectASFIXIA PRENATALes
dc.subjectNEUROPSICOLOGIAes
dc.subjectTRASTORNOS DEL NEURODESARROLLOes
dc.titlePalmitoylethanolamide ameliorates hippocampal damage and behavioral dysfunction after perinatal asphyxia in the immature rat braines
dc.typeArtículoes
uca.pathFacultad de Psicología y Psicopedagogía|Artículoses
uca.disciplinaPSICOLOGIAes
uca.filename/home/data-uca-generic/folder_generic_common/articulos/palmitoylethanolamide-ameliorates-hippocampal-damage/metadata.xmles
uca.issnrd1es
uca.affiliationFil: Herrera, María I. Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentinaes
uca.affiliationFil: Udovin, Lucas Daniel. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas; Argentinaes
uca.affiliationFil: Udovin, Lucas Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Toro-Urrego, Nicolás. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas; Argentinaes
uca.affiliationFil: Toro-Urrego, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Kusnier, Carlos. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas; Argentinaes
uca.affiliationFil: Kusnier, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Luaces, Juan P. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas; Argentinaes
uca.affiliationFil: Luaces, Juan P. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Capani, Francisco. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas; Argentinaes
uca.affiliationFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Capani, Francisco. Universidad Católica Argentina. Facultad de Medicina; Argentinaes
uca.affiliationFil: Capani, Francisco. Universidad Autónoma de Chile; Chilees
uca.ordenISSN 1662-453Xes
uca.versionpublishedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptFacultad de Psicología y Psicopedagogía-
crisitem.author.deptCentro de Investigaciones en Psicología y Psicopedagogía (CIPP)-
crisitem.author.deptFacultad de Psicología y Psicopedagogía-
crisitem.author.deptCentro de Investigaciones en Psicología y Psicopedagogía (CIPP)-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Cardiológicas-
crisitem.author.orcid0000-0003-0342-0628-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
crisitem.author.parentorgDepartamento de Psicología-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
crisitem.author.parentorgDepartamento de Psicología-
crisitem.author.parentorgConsejo Nacional de Investigaciones Científicas y Técnicas-
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