Response to Letter to the Editor “On the targets of fluoxetine”

Abstract

We read the Letter to the Editor entitled “On the targets of Flu-oxetine” by James M. Brimson and Stephen T. Safrany referred to our review entitled “Immunomodulatory effects of fluoxetine: Anew potential pharmacological action for a classic antidepressantdrug?”.The authors consider that many of the effects described forfluoxetine could be due to the activation of sigma-1 receptorsuggesting that this receptor could be the “Novel receptor” on lym-phocytes proposed in our review. While sigma receptors activationis mainly known for their effect on the nervous system, the presence of this receptor on non-neuronal tissues, including immunesystem has been described.